Researcher Portfolio

 
   

Stark, Holger

Department of Structural Dynamics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, Research Group of 3D Electron Cryo-Microscopy, MPI for biophysical chemistry, Max Planck Society  

 

Researcher Profile

 
Position: Research Group of 3D Electron Cryo-Microscopy, MPI for biophysical chemistry, Max Planck Society
Position: Department of Structural Dynamics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons15857

External references

 

Publications

 
  (1 - 25 of 120)
 : Zhang, Z., Kumar, V., Dybkov, O., Will, C. L., Zhong, J., Ludwig, S. E. J., Urlaub, H., Kastner, B., Stark, H., & Lührmann, R. (2024). Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 1012-1019. doi:10.1038/s41586-024-07458-1. [PubMan] : Zhang, Z., Kumar, V., Dybkov, O., Will, C. L., Urlaub, H., Stark, H., & Lührmann, R. (2024). Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO Journal, 43, 1065-1088. doi:10.1038/s44318-024-00052-1. [PubMan] : Vedel, I. M., Prestel, A., Zhang, Z., Skawinska, N. T., Stark, H., Harris, P., Kragelund, B. B., & Peters, G. H. J. (2023). Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand. Structure, 31(6), 689-699.e6. doi:10.1016/j.str.2023.04.004. [PubMan] : Chari, A., & Stark, H. (2023). Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. Annual Review of Biophysics, 52, 391-411. doi:10.1146/annurev-biophys-111622-091300. [PubMan] : Singh, K., Bunzel, G., Graf, B., Yip, K. M., Neumann-Schaal, M., Stark, H., & Chari, A. (2023). Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186(23): e16, pp. 5054-5067. doi:10.1016/j.cell.2023.10.009. [PubMan] : Günenc, A. N., Graf, B., Stark, H., & Chari, A. (2022). Fatty Acid Synthase: Structure, Function, and Regulation. In R. Harris, & J. Marles-Wright (Eds.), Macromolecular Protein Complexes IV: Structure and Function (pp. 1-33). Cham: Springer. doi:10.1007/978-3-031-00793-4_1. [PubMan] : Yi, S.-H., Petrychenko, V., Schliep, J. E., Goyal, A., Linden, A., Chari, A., Urlaub, H., Stark, H., Rodnina, M. V., Adio, S., & Fischer, N. (2022). Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research, 50(9), 5282-5298. doi:10.1093/nar/gkac283. [PubMan] : Zhang, Z., Rigo, N., Dybkov, O., Fourmann, J. B., Will, C. L., Kumar, V., Urlaub, H., Stark, H., & Lührmann, R. (2021). Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596(7871), 296-300. doi:10.1038/s41586-021-03789-5. [PubMan] : Townsend, C., Leelaram, M. N., Agafonov, D. E., Dybkov, O., Will, C. L., Bertram, K., Urlaub, H., Kastner, B., Stark, H., & Lührmann, R. (2020). Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370(6523): eabc3753. doi:10.1126/science.abc3753. [PubMan] : Yip, K. M., Fischer, N., Paknia, E., Chari, A., & Stark, H. (2020). Atomic-resolution protein structure determination by cryo-EM. Nature, 587(7832), 157-161. doi:10.1038/s41586-020-2833-4. [PubMan] : Bertram, K., El Ayoubi, L., Dybkov, O., Agafonov, D., Will, C. L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., & Lührmann, R. (2020). Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell, 80(1), 127-139.e6. doi:10.1016/j.molcel.2020.09.012. [PubMan] : Zhang, Z., Will, C. L., Bertram, K., Dybkov, O., Hartmuth, K., Agafonov, D. E., Hofele, R. V., Urlaub, H., Kastner, B., Lührmann, R., & Stark, H. (2020). Molecular architecture of the human 17S U2 snRNP. Nature, 583(7815), 310-313. doi:10.1038/s41586-020-2344-3. [PubMan] : Singh, K., Graf, B., Linden, A., Sautner, V., Urlaub, H., Tittmann, K., Stark, H., & Chari, A. (2020). Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell, 180(6), 1130-1143.e20. doi:10.1016/j.cell.2020.02.034. [PubMan] : Kastner, B., Will, C. L., Stark, H., & Lührmann, R. (2019). Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology, 11(11): a032417. doi:10.1101/cshperspect.a032417. [PubMan] : Watson, E. R., Grace, C. R. R., Zhang, W., Miller, D. J., Davidson, I. F., Prabu, J. R., Yu, S., Bolhuis, D. L., Kulko, E. T., Vollrath, R., Haselbach, D., Stark, H., Peters, J. M., Brown, N. G., Sidhu, S. S., & Schulman, B. A. (2019). Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America, 116(35), 17280-17289. doi:10.1073/pnas.1902889116. [PubMan] : Prajapati, S., Haselbach, D., Wittig, S., Patel, M. S., Chari, A., Schmidt, C., Stark, H., & Tittmann, K. (2019). Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure, 27(7), 1124-1136. doi:10.1016/j.str.2019.04.009. [PubMan] : Watson, E. R., Brown, N. G., Peters, J. M., Stark, H., & Schulman, B. A. (2019). Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology, 29(2), 117-134. doi:10.1016/j.tcb.2018.09.007. [PubMan] : Renaud, J. P., Chari, A., Ciferri, C., Liu, W., Rémigy, H. W., Stark, H., & Wiesmann, C. (2018). Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery, 17(7), 471-492. doi:10.1038/nrd.2018.77. [PubMan] : Haselbach, D., Komarov, I., Agafonov, D. E., Hartmuth, K., Graf, B., Dybkov, O., Urlaub, H., Kastner, B., Lührmann, R., & Stark, H. (2018). Structure and conformational dynamics of the human spliceosomal Bact complex. Cell, 172(3), 454-464, e1-e5. doi:10.1016/j.cell.2018.01.010. [PubMan] : Bertram, K., Agafonov, D. E., Dybkov, O., Haselbach, D., Leelaram, M. N., Will, C. L., Urlaub, H., Kastner, B., Lührmann, R., & Stark, H. (2017). Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell, 170(4), 701-713, e1 - e4. doi:10.1016/j.cell.2017.07.011. [PubMan] : Haselbach, D., Schrader, J., Lambrecht, F., Henneberg, F., Chari, A., & Stark, H. (2017). Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications, 8: 15578. doi:10.1038/ncomms15578. [PubMan] : Rodnina, M. V., Fischer, N., Maracci, C., & Stark, H. (2017). Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B, 372(1716): 20160182. doi:10.1098/rstb.2016.0182. [PubMan] : Bertram, K., Agafonov, D. E., Liu, W., Dybkov, O., Will, C. L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., & Lührmann, R. (2017). Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature, 542(7641), 318-323. doi:10.1038/nature21079. [PubMan] : Bock, L. V., Fischer, N., Stark, H., & Grubmüller, H. (2017). Dynamics and energetics of elongation factor SelB in the ternary complex and the ribosome. Biophysical Journal, 112(Suppl 1), 49a-49a. [PubMan] : Fischer, N., Neumann, P., Bock, l. V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A. L., Schröder, G. F., Grubmüller, H., Ficner, R., Rodnina, M. V., & Stark, H. (2016). The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature, 540(7631), 80-85. doi:10.1038/nature20560. [PubMan]