Researcher Portfolio

 
   

Prof. Dr. Grosschedl, Rudolf

Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society  

 

Researcher Profile

 
Position: Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons191076

External references

 

Publications

 
  (1 - 25 of 77)
 : Chen, H.-R., Sun, Y., Mittler, G., Rumpf, T., Shvedunova, M., Grosschedl, R., & Akhtar, A. (2024). MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation. Cell Reports, 43: 114682. doi:10.1016/j.celrep.2024.114682. [PubMan] : Phongbunchoo, Y., Braikia, F.-Z., Pessoa-Rodrigues, C., Ramamoorthy, S., Ramachandran, H., Grosschedl, A., Ma, F., Cauchy, P., Akhtar, A., Sen, R., Mittler, G., & Grosschedl, R. (2024). YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment. Cell Reports, 43: 114456. doi:10.1016/j.celrep.2024.114456. [PubMan] : Zolotarev, N., Wang, Y., Du, M., Bayer, M., Grosschedl, A., Cissé, I. I., & Grosschedl, R. (2024). Regularly spaced tyrosines in EBF1 mediate BRG1 recruitment and formation of nuclear subdiffractive clusters. Genes and Development. doi:10.1101/gad.350828.123. [PubMan] : Schleussner, N., Cauchy, P., Franke, V., Giefing, M., Fornes, O., Vankadari, N., Assi, S. A., Costanza, M., Weniger, M. A., Akalin, A., Anagnostopoulos, I., Bukur, T., Casarotto, M. G., Damm, F., Daumke, O., Edginton-White, B., Gebhardt, J. C. M., Grau, M., Grunwald, S., Hansmann, M.-L., Hartmann, S., Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U., Fischer, A., Reisser, A., Rosenwald, A., Schwarz, K., Sundararaj, S., Weilemann, A., Winkler, W., Xu, W., Lenz, G., Rajewsky, K., Wasserman, W. W., Cockerill, P. N., Scheidereit, C., Siebert, R., Küppers, R., Grosschedl, R., Janz, M., Bonifer, C., & Mathas, S. (2023). Transcriptional reprogramming by mutated IRF4 in lymphoma. Nature Communications, 14: 6947. doi:10.1038/s41467-023-41954-8. [PubMan] : Grosschedl, R. (2023). Terri Grodzicker: 35 years of shaping scientific publishing and communication. Genes and Development, 37, 2-3. doi:10.1101/gad.350465.123. [PubMan] : Zolotarev, N., Bayer, M., & Grosschedl, R. (2022). EBF1 is continuously required for stabilizing local chromatin accessibility in pro-B cells. Proceedings of the National Academy of Sciences of the United States of America, 119: e2210595119. doi:10.1073/pnas.2210595119. [PubMan] : Andreani, V., Ramamoorthy, S., Fässler, R., & Grosschedl, R. (2022). Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling. Journal of Experimental Medicine, 220: e20220342. doi:10.1084/jem.20220342. [PubMan] : Bayer, M., Boller, S., Ramamoothy, S., Zolotarev, N., Cauchy, P., Iwanami, N., Mittler, G., Boehm, T., & Grosschedl, R. (2022). Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Genes and Development, 36, 901-915. doi:10.1101/gad.349696.122. [PubMan] : Lenaerts, A., Kucinski, I., Deboutte, W., Derecka, M., Cauchy, P., Manke, T., Göttgens, B., & Grosschedl, R. (2022). EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors. Journal of Experimental Medicine, 219: e20212437. doi:10.1084/jem.20212437. [PubMan] : Qiu, Z., Guo, W., Dong, B., Wang, Y., Deng, P., Wang, C., Liu, J., Zhang, Q., Grosschedl, R., Yu, Z., Deng, J., & Wu, Y. (2022). EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway. Proceedings of the National Academy of Sciences of the United States of America, 119: e2119518119. doi:10.1073/pnas.2119518119. [PubMan] : Bayer, M., & Grosschedl, R. (2022). How to resist Notch-targeted T-leukemia therapy: Lineage- and MYC enhancer switch. Molecular Cell, 82, 884-886. doi:10.1016/j.molcel.2022.02.015. [PubMan] : Roy, R., Ramamoorthy, S., Shapiro, B. D., Kaileh, M., Hernandez, D., Sarantopoulou, D., Arepalli, S., Boller, S., Singh, A., Bektas, A., Kim, J., Moore, A. Z., Tanaka, T., McKelvey, J., Zukley, L., Nguyen, C., Wallace, T., Dunn, C., Wersto, R., Wood, W., Piao, Y., Becker, K. G., Coletta, C., De, S., Sen, J. M., Battle, A., Weng, N.-p., Grosschedl, R., Ferrucci, L., & Sen, R. (2021). DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity. Immunity, 54, 2465-2480. doi:10.1016/j.immuni.2021.10.001. [PubMan] : Antonio Urrutia, G., Ramachandran, H., Cauchy, P., Boo, K., Ramamoorthy, S., Boller, S., Dogan, E., Clapes, T., Trompouki, E., Torres-Padilla, M.-E., Palvimo, J. J., Pichler, A., & Grosschedl, R. (2021). ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Genes and Development, 35, 1143-1160. doi:10.1101/gad.345843.120. [PubMan] : Wang, Y., Zolotarev, N., Yang, C.-Y., Rambold, A., Mittler, G., & Grosschedl, R. (2020). A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin. Immunity, 53, 1151-1167. doi:10.1016/j.immuni.2020.10.009. [PubMan] : Kapoor, T., Corrado, M., Pearce, E. L., Pearce, E. J., & Grosschedl, R. (2020). MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports, 10: 21626. doi:10.1038/s41598-020-78293-3. [PubMan] : Kucinski, I., Wilson, N. K., Hannah, R., Kinston, S. J., Cauchy, P., Lenaerts, A., Grosschedl, R., & Göttgens, B. (2020). Interactions between lineage-associated transcription factors govern haematopoietic progenitor states. The EMBO Journal, 39: e104983. doi:10.15252/embj.2020104983. [PubMan] : Derecka, M., Herman, J. S., Cauchy, P., Ramamoorthy, S., Lupar, E., Grün, D., & Grosschedl, R. (2020). EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential. Nature, 21, 261-273. doi:10.1038/s41590-020-0595-7. [PubMan] : Ramamoorthy, S., Kometani, K., Herman, J. S., Bayer, M., Boller, S., Edwards-Hicks, J., Ramachandran, H., Li, R., Klein-Geltink, R., Pearce, E. L., Grün, D., & Grosschedl, R. (2020). EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes and Development, 34, 1503-1519. doi:10.1101/gad.340216.120. [PubMan] : Tinterri, A., Menardy, F., Diana, M. A., Lokmane, L., Keita, M., Coulpier, F., Lemoine, S., Mailhes, C., Mathieu, B., Merchan-Sala, P., Campbell, K., Gyory, I., Grosschedl, R., Popa, D., & Garel, S. (2018). Active intermixing of indirect and direct neurons builds the striatal mosaic. Nature Communications, 9: 4725 (2018). doi:10.1038/s41467-018-07171-4. [PubMan] : Yanai, H., Chiba, S., Hangai, S., Kometani, K., Inoue, A., Kimura, Y., Abe, T., Kiyonari, H., Nishio, J., Taguchi-Atarashi, N., Mizushima, Y., Negishi, H., Grosschedl, R., & Taniguchi, T. (2018). Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proceedings of the National Academy of Sciences of the United States of America, 115, 5253-5258. doi:org/10.1073/pnas.1803936115. [PubMan] : Boller, S., Li, R., & Grosschedl, R. (2018). Defining B Cell Chromatin: Lessons from EBF1. Trends in Genetics, 34, 257-269. doi:10.1016/j.tig.2017.12.014. [PubMan] : Li, R., Cauchy, P., Ramamoorthy, S., Boller, S., Chevez, L., & Grosschedl, R. (2018). Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Genes and Development, 32, 96-111. doi:10.1101/gad.309583.117. [PubMan] : Andreani, V., Ramamoorthy, S., Pandey, A., Lupar, E., Nutt, S. L., Lämmermann, T., & Grosschedl, R. (2018). Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function. Proceedings of the National Academy of Sciences of the United States of America, 115, E9630-E9639. doi:10.1073/pnas.1809739115. [PubMan] : Musa, Y. R., Boller, S., Puchalska, M., Grosschedl, R., & Mittler, G. (2018). Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Ulilizing Data Independent Acquisition. Journal of Proteome Research, 17, 76-85. doi:10.1021/acs.jproteome.7b00369. [PubMan] : Rodríguez-Gil, A., Ritter, O., Saul, V. V., Wilhelm, J., Yang, C.-Y., Grosschedl, R., Imai, Y., Kuba, K., Kracht, M., & Schmitz, M. L. (2017). The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Scientific Reports, 7: 3547 (2017). doi:10.1038/s41598-017-03708-7. [PubMan]