Researcher Portfolio

Dr. Pospisilik, John Andrew

Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society

Researcher Profile

Position: Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society

Researcher ID: https://pure.mpg.de/cone/persons/resource/persons198873

External references

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Publications

(1 - 25 of 34)

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: Panzeri, I., Fagnocchi, L., Apostle, S., Tompkins, M., Wolfrum, E., Madaj, Z., Hostetter, G., Liu, Y., Schaefer, K., Yang, C.-H., Bergsma, A., Drougard, A., Dror, E., PERMUTE, Chandler, D. P., Schramek, D., Triche Jr, T. J., & Pospisilik, J. A. (2025). TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states. Nature cancer, 6, 385-403. doi:10.1038/s43018-024-00900-3. [PubMan] : Drougard, A., Ma, E. H., Wegert, V., Sheldon, R., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., Völker, J., Pang, S., Bremser, A., Dror, E., Giacona, F., Sagar, S., Henderson, M. X., Prinz, M., Jones, R. G., & Pospisilik, J. A. (2024). An acute microglial metabolic response controls metabolism and improves memory. eLife, 12: RP87120. doi:10.7554/eLife.87120.3. [PubMan] : Boneva, S. K., Wolf, J., Jung, M., Prinz, G., Chui, T. Y. P., Jauch, J., Drougard, A., Pospisilik, J. A., Schlecht, A., Bucher, F., Rosen, R. B., Agostini, H., Schlunck, G., & Lange, C. A. K. (2024). The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy. Journal of Neuroinflammation, 21: 297. doi:10.1186/s12974-024-03291-5. [PubMan] : Seifert, G., Fagnocchi, L., Edozie, M., Herrmann, S., Baumann, H., Panzeri, I., Mewes, S., Aicher, D., Runkel, M., Lässle, C., Fink, J., Marjanovic, G., Fichtner-Feigl, S., & Pospisilik, J. A. (2023). The DECON pilot project investigates predictive markers for successful bariatric surgery. Scientific Reports, 13: 13401. doi:10.1038/s41598-023-40452-7. [PubMan] : Dror, E., Fagnocchi, L., Wegert, V., Apostle, S., Grimaldi, B., Gruber, T., Panzeri, I., Heyne, S., Höffler, K. D., Kreiner, V., Ching, R., Lu, T.-T.-H., Semwal, A., Johnson, B., Senapati, P., Lempradl, A., Schones, D., Imhof, A., Shen, H., & Pospisilik, J. A. (2023). Epigenetic dosage identifies two major and functionally distinct β cell subtypes. Cell Metabolism, 35, 821-836. doi:10.1016/j.cmet.2023.03.008. [PubMan] : Yang, C.-H., Fagnocchi, L., Apostle, S., Wegert, V., Casaní-Galdón, S., Landgraf, K., Panzeri, I., Dror, E., Heyne, S., Wörpel, T., Chandler, D. P., Lu, D., Yang, T., Gibbons, E., Guerreiro, R., Bras, J., Thomasen, M., Grunnet, L. G., Vaag, A. A., Gillberg, L., Grundberg, E., Conesa, A., Körner, A., PERMUTE, & Pospisilik, J. A. (2022). Independent phenotypic plasticity axes define distinct obesity sub-types. Nature Metabolism, 4, 1150-1165. doi:10.1038/s42255-022-00629-2. [PubMan] : Yang, C.-H., Longinotto, J., Panzeri, I., Arrigoni, L., Wegert, V., Heyne, S., Seifert, G., Lempradl, A., Bönisch, U., & Pospisilik, J. A. (2022). Isolation and Processing of Murine White Adipocytes for Transcriptome and Epigenome Analyses. Journal of Visualized Experiments, 184: e64128. doi:10.3791/64128. [PubMan] : Ramisch, A., Heinrich, V., Glaser, L. V., Fuchs, A., Yang, X., Benner, P., Schöpflin, R., Li, N., Kinkley, S., Römer-Hillmann, A., Longinotto, J., Heyne, S., Czepukojc, B., Kessler, S. M., Kiemer, A. K., Cadenas, C., Arrigoni, L., Gasparoni, N., Manke, T., Pap, T., Pospisilik, A., Hengstler, J., Walter, J., Meijsing, S. H., Chung, H.-R., & Vingron, M. (2019). CRUP: a comprehensive framework to predict condition-specific regulatory units. Genome Biology: Biology for the Post-Genomic Era, 20, 227. doi:10.1186/s13059-019-1860-7. [PubMan] : Timper, K., Paeger, L., Sánchez-Lasheras, C., Varela, L., Jais, A., Nolte, H., Vogt, M. C., Hausen, C., Heilinger, C., Evers, N., Pospisilik, J. A., Penninger, J. M., Taylor, E. B., Horvath, T. L., Kloppenburg, P., & Brüning, J. C. (2018). Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Reports, 25, 383-397. doi:10.1016/j.celrep.2018.09.034. [PubMan] : Arrigoni, L., Al-Hasani, H., Ramírez, F., Panzeri, I., Ryan, D. P., Santacruz, D., Kress, N., Pospisilik, J. A., Bönisch, U., & Manke, T. (2018). RELACS nuclei barcoding enables high-throughput ChIP-seq. Communications Biology, 214. doi:10.1038/s42003-018-0219-z. [PubMan] : Panzeri, I., & Pospisilik, J. A. (2018). Epigenetic control of variation and stochasticity in metabolic disease. Molecular Metabolism, 14, 26-38. doi:10.1016/j.molmet.2018.05.010. [PubMan] : Timper, K., Paeger, L., Sanchez-Lasheras, C., Varela, L., Jais, A., Nolte, H., Vogt, M. C., Hausen, A. C., Heilinger, C., Evers, N., Pospisilik, J. A., Penninger, J. M., Taylor, E. B., Horvath, T. L., Kloppenburg, P., & Brüning, J. C. (2018). Mild impairment of mitochondrial OXPHOS promotes fatty acid utilization in POMC neurons and improves glucose homeostasis in obesity. Cell Reports, 25(2), 383-397. doi:10.1016/j.celrep.2018.09.034. [PubMan] : Lu, T.-T.-H., Heyne, S., Dror, E., Casas, E., Leonhardt, L., Boenke, T., Yang, C.-H., Sagar, S., Arrigoni, L., Dalgaard, K., Teperino, R., Enders, L., Selvaraj, M., Ruf, M., Raja, S. J., Xie, H., Boenisch, U., Orkin, S. H., Lynn, F. C., Hoffman, B. G., Grün, D., Vavouri, T., Lempradl, A. M., & Pospisilik, J. A. (2018). The Polycomb-Dependent Epigenome Controls β Cell Cysfunction, Dedifferentiation, and Diabetes. Cell Metabolism, 15, 1294-1308. doi:doi.org/10.1016/j.cmet.2018.04.013. [PubMan] : Costantino, S., Paneni, F., Virdis, A., Hussain, S., Mohammed, S. A., Capretti, G., Akhmedov, A., Dalgaard, K., Chiandotto, S., Pospisilik, J. A., Jenuwein, T., Giorgio, M., Volpe, M., Taddei, S., Lüscher, T. F., & Cosentino, F. (2017). Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66^Shc transcription and vascular oxidative stress in obesity. European Heart Journal, 40, 383-391. doi:10.1093/eurheartj/ehx615. [PubMan] : Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, S., Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., Staszewski, O., Margineanu, A., Sporbert, A., Steinmetz, L. M., Pospisilik, J. A., Jung, S., Priller, J., Grün, D., Ronneberger, O., & Prinz, M. (2017). A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nature Neuroscience, 20, 793-803. doi:10.1038/nn.4547. [PubMan] : Theurich, S., Tsaousidou, E., Hanssen, R., Lempradl, A. M., Mauer, J., Timper, K., Schilbach, K., Folz-Donahue, K., Heilinger, C., Sexl, V., Pospisilik, J. A., Wunderlich, F. T., & Brüning, J. C. (2017). IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis. Cell Metabolism, 26(1), 171-184. doi:10.1016/j.cmet.2017.05.018. [PubMan] : Dalgaard, K., Landgraf, K., Heyne, S., Lempradl, A., Longinotto, J., Gossens, K., Ruf, M., Orthofer, M., Strogantsev, R., Selvaraj, M., Lu, T.-T.-H., Casas, E., Teperino, R., Surani, M. A., Zvetkova, I., Rimmington, D., Tung, Y. L., Lam, B., Larder, R., Yeo, G. S., O’Rahilly, S., Vavouri, T., Whitelaw, E., Penninger, J. M., Jenuwein, T., Cheung, C.-L., Ferguson-Smith, A. C., Coll, A. P., Körner, A., & Pospisilik, J. A. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell, 164, 353-364. doi:10.1016/j.cell.2015.12.025. [PubMan] : Lempradl, A., Pospisilik, J. A., & Penninger, J. M. (2015). Exploring the emerging complexity in transcription regulation of energy homeostasis. Nature Reviews Genetics, 16, 665-681. doi:doi: 10.1038/nrg3941. [PubMan] : Öst, A., & Pospisilik, J. A. (2015). Epigenetic modulation of metabolic decisions. Current Opinion in Cell Biology, 33, 88-94. doi: doi: 10.1016/j.ceb.2014.12.005. [PubMan] : Teperino, R., & Pospisilik, J. A. (2015). Determination and analysis of Cellular Metabolic Changes by Noncanonical Hedgehog Signaling. In Methods in Molecular Biology (pp. 187-198). New York: Springer Science + Business Media. [PubMan] : Oest, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., Ruf, M., Rajewsky, N., Reuter, G., Iovino, N., Ribiero, C., Alenius, M., Heyne, S., Vavouri, T., & Pospisilik, J. A. (2014). Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity. Cell, 159, 1352-1364. [PubMan] : Jais, A., Einwallner, E., Sharif, O., Gossens, K., Tsai-Hsiu Lu, T., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., Duvigneau, J. C., Lindroos-Christensen, J., Zapf, T.-C., Amann, S., Saluzzo, S., Jantscher, F., Stiedl, P., Todoric, J., Martins, R., Oberkofler, H., Müller, S., Hauser-Kronberger, C., Kenner, L., Casanova, E., Sutterlüty-Fall, H., Bilban, M., Miller, K., Kozlov, A. V., Krempler, F., Knapp, S., Lumeng, C. N., Patsch, W., Wagner, O., Pospisilik, J. A., & Esterbauer, H. (2014). Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. Cell, 158, 25-40. [PubMan] : Teperino, R., Aberger, F., Esterbauer, H., Riobo, N., & Pospisilik, J. A. (2014). Canonical and non-canonical Hedgehog signalling and the control of metabolism. Seminars in Cell & Developmental Biology, 33, 81-92. [PubMan] : Lindroos, J., Husa, J., Mitterer, G., Haschemi, A., Rauscher, S., Haas, R., Gröger, M., Loewe, R., Kohrgruber, N., Schrögendorfer, K. F., Prager, G., Beck, H., Pospisilik, J. A., Zeyda, M., Stulnig, T. M., Patsch, W., Wagner, O., Esterbauer, H., & Bilban, M. (2013). Human but Not Mouse Adipogenesis Is Critically Dependent on LMO3. Cell Metabolism, 18, 62-74. [PubMan] : Pospisilik, J. A. (2013). Metabolism shaping chromatin shaping metabolism. Cellular and Molecular Life Sciences, 70, 1493-1494. [PubMan]