Researcher Portfolio
Dr. Akhtar, Asifa
Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society
Researcher Profile
Position: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons198888
Publications
(1 - 25 of 72)
: Wogram, E., Sümpelmann, F., Dong, W., Rawat, E., Maestre, I. F., Fu, D., Braswell, B., Khalil, A., Büscher, J. M., Mittler, G., Borner, G. H. H., Vlachos, A., Tholen, S., Schilling, O., Bell, G. W., Rambold, A., Akhtar, A., Schnell, O., Beck, J., Abu-Reh, M., Prinz, M., & Jaenisch, R. (2024). Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes. Immunity, 57, 2216-2231. doi:10.1016/j.immuni.2024.07.019. [PubMan] : Chen, H.-R., Sun, Y., Mittler, G., Rumpf, T., Shvedunova, M., Grosschedl, R., & Akhtar, A. (2024). MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation. Cell Reports, 43: 114682. doi:10.1016/j.celrep.2024.114682. [PubMan] : Phongbunchoo, Y., Braikia, F.-Z., Pessoa-Rodrigues, C., Ramamoorthy, S., Ramachandran, H., Grosschedl, A., Ma, F., Cauchy, P., Akhtar, A., Sen, R., Mittler, G., & Grosschedl, R. (2024). YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment. Cell Reports, 43: 114456. doi:10.1016/j.celrep.2024.114456. [PubMan] : Kulkarni, T., & Akhtar, A. (2024). Nuclei facing the tissue surface get fuel for development. Nature, 630, 312-314. doi:10.1038/d41586-024-01503-9. [PubMan] : Zhou, Y., Panhale, A., Shvedunova, M., Balan, M., Gomez-Auli, A., Holz, H., Seyfferth, J., Helmstädter, M., Kayser, S., Zhao, Y., Erdogdu, N. U., Grzadzielewska, I., Mittler, G., Manke, T., & Akhtar, A. (2024). RNA damage compartmentalization by DHX9 stress granules. Cell, 187, 1701-1718. doi:10.1016/j.cell.2024.02.028. [PubMan] : Sun, Y., Wiese, M., Hmadi, R., Karayol, R., Seyfferth, J., Greene, J. A. M., Erdogdu, N. U., Deboutte, W., Arrigoni, L., Holz, H., Renschler, G., Hirsch, N., Foertsch, A., Basilicata, M. F., Stehle, T., Shvedunova, M., Bella, C., Rodrigues, C. P., Schwalb, B., Cramer, P., Manke, T., & Akhtar, A. (2023). MSL2 ensures biallelic gene expression in mammals. Nature, 624, 173-181. doi:10.1038/s41586-023-06781-3. [PubMan] : Guhathakurta, S., Erdogdu, N. U., Hoffmann, J. J., Grzadzielewska, I., Schendzielorz, A., Seyfferth, J., Mårtensson, C. U., Corrado, M., Karoutas, A., Warscheid, B., Pfanner, N., Becker, T., & Akhtar, A. (2023). COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nature Metabolism, 5, 1931-1952. doi:.1038/s42255-023-00904-w. [PubMan] : Tsang, T. H., Wiese, M., Helmstädter, M., Stehle, T., Seyfferth, J., Shvedunova, M., Holz, H., Walz, G., & Akhtar, A. (2023). Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells. Science Advances, 9: eadh5598. doi:10.1126/sciadv.adh5598. [PubMan] : Iyer, S. S., Sun, Y., Seyfferth, J., Manjunath, V., Samata, M., Alexiadis, A., Kulkarni, T., Gutierrez, N., Georgiev, P., Shvedunova, M., & Akhtar, A. (2023). The NSL complex is required for piRNA production from telomeric clusters. Life science alliance, 6: e202302194. doi:10.26508/lsa.202302194. [PubMan] : Akhtar, A. (2023). Asifa Akhtar. Current Biology, 33, R286-R287. doi:10.1016/j.cub.2023.03.040. [PubMan] : Shvedunova, M., & Akhtar, A. (2022). Modulation of cellular processes by histone and non-histone protein acetylation. Nature Reviews Molecular Cell Biology, 23, 329-349. doi:10.1038/s41580-021-00441-y. [PubMan] : Pessoa Rodrigues, C., Chatterjee, A., Wiese, M., Stehle, T., Szymanski, W. G., Shvedunova, M., & Akhtar, A. (2021). Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice. Nature Communications, 12: 6212. doi:10.1038/s41467-021-26277-w. [PubMan] : Pessoa Rodrigues, C., & Akhtar, A. (2021). Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science Advances, 7(32): eabi5987. doi:10.1126/sciadv.abi5987. [PubMan] : Keller Valsecchi, C. I., Marois, E., Basilicata, M. F., Georgiev, P., & Akhtar, A. (2021). Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life science alliance, 4: e202000996. doi:10.26508/lsa.202000996. [PubMan] : Clapes, T., Polyzou, A., Prater, P., Sagar, Morales-Hernández, A., Ferrarini, M. G., Kehrer, N., Lefkopoulos, S., Bergo, V., Hummel, B., Obier, N., Maticzka, D., Bridgeman, A., Herman, J. S., Ilik, I., Klaeylé, L., Rehwinkel, J., McKinney-Freeman, S., Backofen, R., Akhtar, A., Cabezas-Wallscheid, N., Sawarkar, R., Rebollo, R., Grün, D., & Trompouki, E. (2021). Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology, 23, 704-717. doi:10.1038/s41556-021-00707-9. [PubMan] : Karoutas, A., & Akhtar, A. (2021). Functional mechanisms and abnormalities of the nuclear lamina. Nature Cell Biology, 23, 116-126. doi:10.1038/s41556-020-00630-5. [PubMan] : Keller Valsecchi, C. I., Basilicata, M. F., Georgiev, P., Gaub, A., Seyfferth, J., Kulkarni, T., Panhale, A., Semplicio, G., Manjunath, V., Holz, H., Dasmeh, P., & Akhtar, A. (2020). RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature, 589, 137-142. doi:10.1038/s41586-020-2935-z. [PubMan] : Pessoa Rodrigues, C., Shvedunova, M., & Akhtar, A. (2020). Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics, 37, 125-142. doi:10.1016/j.tig.2020.09.015. [PubMan] : Samata, M., Alexia, A., Richard, G., Georgiev, P., Nuebler, J., Kulkarni, T., Renschler, G. V., Basilicata, M. F., Zenk, F. L., Shvedunova, M., Semplicio, G., Mirny, L., Iovino, N., & Akhtar, A. (2020). Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell, 182, 127-144. doi:org/10.1016/j.cell.2020.05.026. [PubMan] : Sheikh, B. N., Guhathakurta, S., Tsang, T. H., Schwabenland, M., Renschler, G. V., Herquel, B., Bhardwaj, V., Holz, H., Stehle, T., Bondareva, O., Aizarni, N., Mossad, O., Kretz, O., Reichardt, W., Chatterjee, A., Braun, L. J., Thevenon, J., Sartelet, H., Blank, T., Grün, D., von Elverfeldt, D., Huber, T. B., Vestweber, D., Avilov, S., Prinz, M., Büscher, J. M., & Akhtar, A. (2020). Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology, 22, 828-841. doi:org/10.1038/s41556-020-0526-8. [PubMan] : Ilik, I. A., Aktas, T., Maticzka, D., Backofen, R., & Akhtar, A. (2020). FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research, 48, e15. doi:10.1093/nar/gkz1141. [PubMan] : Ilik, I. A., Aktas, T., Maticzka, D., Backofen, R., & Akhtar, A. (2020). FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research, 48(3): e15. doi:10.1093/nar/gkz1141. [PubMan] : Gaub, A., Sheikh, B. N., Basilicata, M. F., Vincent, M., Nizon, M., Colson, C., Bird, M. J., Bradner, J. E., Thevenon, J., Boutros, M., & Akhtar, A. (2020). Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications, 11, 2243. doi: 10.1038/s41467-020-16103-0. [PubMan] : Estrada Mallarino, L., Engel, C., Ilik, I. A., Maticzka, D., Heyl, F., Müller, B., Yakulov, T. A., Dengjel, J., Backofen, R., Akhtar, A., & Walz, G. (2020). Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Scientific Reports, 10, 1-14. doi:org/10.1038/s41598-020-72905-8. [PubMan] : Rodrigues, C. P., Herman, J. S., Herquel, B., Velsecchi Keller, C. I., Stehle, T., Grün, D., & Akhtar, A. (2020). Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances, 6, eaaz4815. doi:10.1126/sciadv.aaz4815. [PubMan]