Researcher Portfolio
Dr. Hilgers, Valérie
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society
Researcher Profile
Position: Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons201444
Publications
: Grzejda, D., Hess, A., Rezansoff, A., Gorey, S., Carrasco, J., Alfonso-Gonzalez, C., Tsagkris, S., Neuhaus, L., Shi, M., Ozbulut, H. C., Vögtle, F.-N., Vlachos, A., & Hilgers, V. (2025). Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. EMBO Reports. doi:10.1038/s44319-025-00401-z. [PubMan] : Ozbulut, H. C., & Hilgers, V. (2024). Neuronal RNA processing: cross-talk between transcriptional regulation and RNA-binding proteins. Frontiers in Molecular Neuroscience, 17. doi:10.3389/fnmol.2024.1426410. [PubMan] : Alfonso-Gonzalez, C., & Hilgers, V. (2024). (Alternative) transcription start sites as regulators of RNA processing. Trends in Cell Biology, 34, 1018-1028. doi:10.1016/j.tcb.2024.02.010. [PubMan] : Alfonso-Gonzalez, C., Arrigoni, L., Ozbulut, H. C., Falk, S., Bönisch, U., & Hilgers, V. (2023). Identification of regulatory links between transcription and RNA processing with long-read sequencing. STAR Protocols, 4: 102505. doi:10.1016/j.xpro.2023.102505. [PubMan] : Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H. C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N., & Hilgers, V. (2023). Sites of transcription initiation drive mRNA isoform selection. Cell, 186, 2438-2455. doi:10.1016/j.cell.2023.04.012. [PubMan] : Carrasco, J., Mateos, F., & Hilgers, V. (2022). A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation. Cell Reports, 41: 111542. doi:10.1016/j.celrep.2022.111542. [PubMan] : Grzejda, D., Mach, J., Schweizer, J. A., Hummel, B., Rezansoff, A. M., Eggenhofer, F., Panhale, A., Lalioti, M.-E., Cabezas-Wallscheid, N., Backofen, R., Felsenberg, J., & Hilgers, V. (2022). The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity. Science Advances, 8: eabo5578. doi:10.1126/sciadv.abo5578. [PubMan] : Hilgers, V. (2022). Regulation of neuronal RNA signatures by ELAV/Hu proteins. Wiley interdisciplinary reviews: WIREs RNA, e1733. doi:10.1002/wrna.1733. [PubMan] : Castro Alvarez, J. J., Revel, M., Carrasco Sala, J., Cléard, F., Pauli, D., Hilgers, V., Karch, F., & Maeda, R. K. (2021). Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference. PLoS Genetics, 17(11): e1009843. doi:10.1371/journal.pgen.1009843. [PubMan] : Carrasco, J., Rauer, M., Hummel, B., Grzejda, D., Alfonso-Gonzalez, C., Lee, Y., Wang, Q., Puchalska, M., Mittler, G., & Hilgers, V. (2020). ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue. Molecular Cell, 80, 156-163. doi:10.1016/j.molcel.2020.09.011. [PubMan] : Wang, Q., Taliaferro, J. M., Klibaite, U., Hilgers, V., Shaevitz, J. W., & Rio, D. C. (2016). The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 113, 5269-5274. doi:10.1073/pnas.1600936113. [PubMan] : Oktaba, K., Zhang, W., Lotz, T. S., Jun, D. J., Lemke, S. B., Ng, S. P., Esposito, E., Levine, M., & Hilgers, V. (2015). ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervious system. Molecular Cell, 57, 341-348. doi:10.1016/j.molcel.2014.11.024. [PubMan] : Hilgers, V. (2015). Alternative polyadenylation couples to transcription initiation: Insights from ELAV-mediated 3' UTR extension. RNA Biology, 12, 918-921. doi:10.1080/15476286.2015.1060393. [PubMan] : Hilgers, V., Lemke, S. B., & Levine, M. (2012). ELAV mediates 3' UTR extension in the Drosophila nervous system. Proceedings of the National Academy of Sciences of the United States of America, 26, 2259-2264. doi:10.1101/gad.199653.112. [PubMan] : Hilgers, V., Perry, M. W., Hendrix, D., Stark, A., Levine, M., & Haley, B. (2011). Neural-specific elongation of 3' UTRs during Drosophila development. Proceedings of the National Academy of Sciences of the United States of America, 108, 15864-15869. doi:10.1073/pnas.1112672108. [PubMan] : Hilgers, V., Bushati, N., & Cohen, S. M. (2010). Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biology, 8, e1000396. doi:10.1371/journal.pbio.1000396. [PubMan]