Researcher Portfolio

 
   

Karayel, Oezge

Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society  

 

Researcher Profile

 
Position: Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons213408

External references

 
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Publications

 
  (1 - 25 of 30)
 : Gottemukkala, K. V., Chrustowicz, J., Sherpa, D., Sepic, S., Tung Vu, D., Karayel, O., Papadopoulou, E. C., Gross, A., Schorpp, K., von Gronau, S., Hadian, K., Murray, P. J., Mann, M., Schulman, B. A., & Alpi, A. F. (2024). Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell, 84(10), 1948-1963.e11. doi:10.1016/j.molcel.2024.04.014. [PubMan] : Chrustowicz, J., Sherpa, D., Li, J., Langlois, C. R., Papadopoulou, E. C., Tung Vu, D., Hehl, L. A., Karayel, Ö., Beier, V., Gronau, S. v., Müller, J., Prabu, J. R., Mann, M., Kleiger, G., Alpi, A. F., & Schulman, B. A. (2024). Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell, 84(2), 293-308. doi:10.1016/j.molcel.2023.11.027. [PubMan] : Schmidt, S., Stautner, C., Tung Vu, D., Heinz, A., Regensburger, M., Karayel, O., Truembach, D., Artati, A., Kaltenhaeuser, S., Nassef, M. Z., Hembach, S., Steinert, L., Winner, B., Juergen, W., Jastroch, M., Luecken, M. D., Theis, F. J., Westmeyer, G. G., Adamski, J., Mann, M., Hiller, K., Giesert, F., Weisenhorn, D. M. V., & Wurst, W. (2023). A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease. Nature Communications, 14(1): 7674. doi:10.1038/s41467-023-42862-7. [PubMan] : Schweizer, L., Schaller, T., Zwiebel, M., Karayel, O., Müller-Reif, J. B., Zeng, W.-F., Dintner, S., Nordmann, T. M., Hirschbuehl, K., Maerkl, B., Claus, R., & Mann, M. (2023). Quantitative multiorgan proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammation. EMBO Molecular Medicine, 15(9): e17459. doi:10.15252/emmm.202317459. [PubMan] : Sherpa, D., Mueller, J., Karayel, Ö., Xu, P., Yao, Y., Chrustowicz, J., Gottemukkala, K. V., Baumann, C. A., Gross, A., Czarnecki, O., Zhang, W., Gu, J., Nilvebrant, J., Sidhu, S. S., Murray, P. J., Mann, M., Weiss, M. J., Schulman, B. A., & Alpi, A. F. (2022). Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife, 11: e77937. doi:10.7554/eLife.77937. [PubMan] : Skowronek, P., Thielert, M., Voytik, E., Tanzer, M. C., Hansen, F. M., Willems, S., Karayel, O., Brunner, A.-D., Meier, F., & Mann, M. (2022). Rapid and in-depth coverage of the (phospho-) proteome with deep libraries and optimal window design for dia-PASEF. Molecular & Cellular Proteomics, 21(9): 100279. doi:10.1016/j.mcpro.2022.100279. [PubMan] : Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M., & Kalofonos, H. P. (2022). Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. Neoplasia, 33: 100836. doi:10.1016/j.neo.2022.100836. [PubMan] : Mehta, S., Buyanbat, A., Kai, Y., Karayel, O., Goldman, S. R., Seruggia, D., Zhang, K., Fujiwara, Y., Donovan, K. A., Zhu, Q., Yang, H., Nabet, B., Gray, N. S., Mann, M., Fischer, E. S., Adelman, K., & Orkin, S. H. (2022). Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degra-dation of BCL11A protein in erythroid cells. Cell Chemical Biology, 29(8), 1273-1287. doi:10.1016/j.chembiol.2022.06.007. [PubMan] : Steger, M., Karayel, Ö., & Demichev, V. (2022). Ubiquitinomics: History, methods, and applications in basic research and drug discovery. Proteomics, 22(15-16): e2200074. doi:10.1002/pmic.202200074. [PubMan] : Karayel, O., Winter, S., Padmanabhan, S., Kuras I, Y., Tung Vu, D., Tuncali, I., Merchant, K., Wills, A.-M., Scherzer, C. R., & Mann, M. (2022). Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease. Cell Reports Medicine, 3(6): 100661. doi:10.1016/j.xcrm.2022.100661. [PubMan] : Langlois, C. R., Beier, V., Karayel, O., Chrustowicz, J., Sherpa, D., Mann, M., & Schulman, B. A. (2022). A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. EMBO Reports, 23(6): e53835. doi:10.15252/embr.202153835. [PubMan] : Qiao, S., Lee, C.-W., Sherpa, D., Chrustowicz, J., Cheng, J. D., Duennebacke, M., Steigenberger, B., Karayel, O., Tung Vu, D., Gronau, S. v., Mann, M., Wilfling, F., & Schulman, B. (2022). Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications, 13(1): 3041. doi:10.1038/s41467-022-30803-9. [PubMan] : Bludau, I., Willems, S., Zeng, W.-F., Strauss, M. T., Hansen, F. M., Tanzer, M. C., Karayel, O., Schulman, B. A., & Mann, M. (2022). The structural context of posttranslational modifications at a proteome-wide scale. PLoS Biology, 20(5): e3001636. doi:10.1371/journal.pbio.3001636. [PubMan] : Kutzner, K., Woods, S., Karayel, O., Gehring, T., Yin, H., Flatley, A., Grass, C., Wimberger, N., Tofaute, M. J., Seeholzer, T., Feederle, R., Mann, M., & Krappmann, D. (2022). Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells. Science Signaling, 15(723): eabk3083. doi:10.1126/scisignal.abk3083. [PubMan] : Yin, H., Karayel, O., Chao, Y.-Y., Seeholzer, T., Hamp, I., Plettenburg, O., Gehring, T., Zielinski, C., Mann, M., & Krappmann, D. (2022). A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kappa B signaling in activated T cells. Cellular and Molecular Life Sciences, 79(2): 112. doi:10.1007/s00018-022-04154-z. [PubMan] : Liwocha, J., Krist, D. T., van der Heden van Noort, G., Hansen, F. M., Truong, V., Karayel, O., Purser, N., Houston, D., Burton, N., Bostock, M., Sattler, M., Mann, M., Harrison, J., Kleiger, G., Ovaa, H., & Schulman, B. A. (2021). Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology, 17, 272-279. doi:10.1038/s41589-020-00696-0. [PubMan] : Sherpa, D., Chrustowicz, J., Qiao, S., Langlois, C. R., Hehl, L. A., Gottemukkala, K. V., Hansen, F. M., Karayel, O., von Gronau, S., Prabu, J. R., Mann, M., Alpi, A. F., & Schulman, B. A. (2021). GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell, 81(11), 2445-2459.e13. doi:10.1016/j.molcel.2021.03.025. [PubMan] : Virreira-Winter, S., Karayel, O., Strauss, M. T., Padmanabhan, S., Surface, M., Merchant, K., Alcalay, R. N., & Mann, M. (2021). Urinary proteome profiling for stratifying patients with familial Parkinson's disease. Embo Molecular Medicine, 13(3): e13257. doi:10.15252/emmm.202013257. [PubMan] : Hansen, F. M., Tanzer, M. C., Brüning, F., Bludau, I., Stafford, C., Schulman, B. A., Robles, M. S., Karayel, O., & Mann, M. (2021). Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nature Communications, 12(1): 254. doi:10.1038/s41467-020-20509-1. [PubMan] : Stukalov, A., Girault, V., Grass, V., Karayel, O., Bergant, V., Urban, C., Haas, D. A., Huang, Y., Oubraham, L., Wang, A., Hamad, M. S., Piras, A., Hansen, F. M., Tanzer, M. C., Paron, I., Zinzula, L., Engleitner, T., Reinecke, M., Lavacca, T. M., Ehmann, R., Woelfel, R., Jores, J., Kuster, B., Protzer, U., Rad, R., Ziebuhr, J., Thiel, V., Scaturro, P., Mann, M., & Pichlmair, A. (2021). Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature, 594(7862), 246-252. doi:10.1038/s41586-021-03493-4. [PubMan] : Karayel, O., Michaelis, A. C., Mann, M., Schulman, B. A., & Langlois, C. R. (2020). DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift. Proceedings of the National Academy of Sciences of the United States of America, 117(51): 202020197. doi:10.1073/pnas.2020197117. [PubMan] : Karayel, Ö., Xu, P., Bludau, I., Velan Bhoopalan, S., Yao, Y., Ana Rita, F., Santos, A., Schulman, B. A., Alpi, A. F., Weiss, M., & Mann, M. (2020). Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology, 16(12): e9813. doi:10.15252/msb.20209813. [PubMan] : Karayel, Ö., Tonelli, F., Virreira Winter, S., Geyer, P. E., Fan, Y., Sammler, E. M., Alessi, D. R., Steger, M., & Mann, M. (2020). Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Molecular and Cellular Proteomics, 19(9), 1546-1560. doi:10.1074/mcp.RA120.002055. [PubMan] : Karayel, Ö. (2020). Development of sensitive and quantitative proteomics strategies to study phospho- and ubiquitin-signaling in health and disease. PhD Thesis, LMU München, Fakultät für Chemie und Pharmazie. [PubMan] : Langlois, C. R., Qiao, S., Sherpa, D., Chrustowicz, J., Beier, V., Karayel, O., & Schulman, B. (2020). The GID E3 Ubiquitin Ligase Converts Between Anticipatory and Active States Through the Incorporation of Swappable Substrate Receptors. The FASEB Journal, 34, 1-1. [PubMan]