Researcher Portfolio
Nuhn, Lutz
Dept. Weil: Synthesis of Macromolecules, MPI for Polymer Research, Max Planck Society, Emmy Noether Group Nuhn: Macromolecular Therapeutics, MPI for Polymer Research, Max Planck Society, Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany, Johannes Gutenberg Univ Mainz, Inst Phys Chem, Mainz, Germany, Julius-Maximilians-Univ, Würzburg, Germany, MIT, David H Koch Inst Integrat Canc Res, Cambridge, USA, MIT, Dept Chem Engn, Cambridge, USA, Univ Ghent, Canc Res Inst Ghent, Ghent, Belgium, Univ Ghent, Dept Pharmaceut, Ghent, Belgium
Researcher Profile
Position: Dept. Weil: Synthesis of Macromolecules, MPI for Polymer Research, Max Planck Society
Position: Univ Ghent, Dept Pharmaceut, Ghent, Belgium
Position: Univ Ghent, Canc Res Inst Ghent, Ghent, Belgium
Position: Johannes Gutenberg Univ Mainz, Inst Phys Chem, Mainz, Germany
Position: Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany
Position: MIT, David H Koch Inst Integrat Canc Res, Cambridge, USA
Position: MIT, Dept Chem Engn, Cambridge, USA
Position: Emmy Noether Group Nuhn: Macromolecular Therapeutics, MPI for Polymer Research, Max Planck Society
Position: Julius-Maximilians-Univ, Würzburg, Germany
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons224635
Publications
(1 - 25 of 111)
: Bixenmann, L., Hauck, A. V., Ahmad, T., & Nuhn, L. (2025). Immunodrug Delivery by Self-Accelerating Degradable Polycarbonate Micelles with Transiently Stable Hemiacetal Ester Side Chains. Macromolecules. doi:10.1021/acs.macromol.4c02729. [PubMan] : Bixenmann, L., & Nuhn, L. (2025). Hemiacetal Ester Side Chains as a Mild Protecting Group for Carboxylic Acids in Polycarbonate Backbones. Macromolecular Rapid Communications, 2500082. doi:10.1002/marc.202500082. [PubMan] : Komforth, P., Imschweiler, J., Hesse, M., Heck, A. G., Fuchs, A., Hauck, A. V., & Nuhn, L. (2025). Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification. Biomacromolecules, 26(1), 384-404. doi:10.1021/acs.biomac.4c01207. [PubMan] : Hauck, A. V., Komforth, P., Erlenbusch, J., Stickdorn, J., Radacki, K., Braunschweig, H., Besenius, P., Hercke, S. V., & Nuhn, L. (2024). Aliphatic polycarbonates with acid degradable ketal side groups as multi-pH-responsive immunodrug nanocarriers. Biomaterials Science, 13(6), 1414-1425. doi:10.1039/d4bm00949e. [PubMan] : Bixenmann, L., Ahmad, T., Stephan, F., & Nuhn, L. (2024). End-Group Dye-Labeled Poly(hemiacetal ester) Block Copolymers: Enhancing Hydrolytic Stability and Loading Capacity for Micellar (Immuno-)Drug Delivery. Biomacromolecules, 25(12), 7958-7974. doi:10.1021/acs.biomac.4c01229. [PubMan] : Heck, A., & Nuhn, L. (2024). Restoring the pH-responsiveness for amine-conjugated 2-propionic-3-methylmaleic anhydride linkers. Organic Chemistry Frontiers, 11(16), 4380-4384. doi:10.1039/D4QO01077A. [PubMan] : Heck, A., Schwiertz, D., Lantzberg, B., Nguyen, H.-C., Forster, R., Scherger, M., Opatz, T., Ginderachter, J. A. V., & Nuhn, L. (2024). Introducing Targeting Units or pH-Releasable Immunodrugs into Core-Clickable Nanogels. European Polymer Journal, 214: 113150. doi:10.1016/j.eurpolymj.2024.113150. [PubMan] : Scherger, M., Pilger, Y. A., Komforth, P., Räder, H. J., & Nuhn, L. (2024). Reversible Polymer-Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers. ACS Biomaterials Science & Engineering, 10(1), 129-138. doi:10.1021/acsbiomaterials.2c01106. [PubMan] : Scherger, M., Pilger, Y. A., Stickdorn, J., Komforth, P., Schmitt, S., Arnouk, S. M., Lebegge, E., Koynov, K., Räder, H. J., Van Ginderachter, J. A., & Nuhn, L. (2023). Self‐Immolative Nanobody‐Cysteine Residue Modification for Controlled Immunodrug Delivery. Advanced Therapeutics, 6(11): 2300076. doi:10.1002/adtp.202300076. [PubMan] : Stickdorn, J., Czysch, C., Medina-Montano, C., Stein, L., Xu, L., Scherger, M., Schild, H., Grabbe, S., & Nuhn, L. (2023). Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses. International Journal of Molecular Sciences, 24(20): 15417. doi:10.3390/ijms242015417. [PubMan] : Scherger, M., Pilger, Y. A., Stickdorn, J., Komforth, P., Schmitt, S., Koynov, K., Räder, H. J., & Nuhn, L. (2023). Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery. Biomacromolecules, 24(5), 2380-2391. doi:10.1021/acs.biomac.3c00239. [PubMan] : Prudlik, A., Mohebbati, N., Hildebrandt, L., Heck, A., Nuhn, L., & Francke, R. (2022). TEMPO-Modified Polymethacrylates as Mediators in Electrosynthesis: Influence of the Molecular Weight on Redox Properties and Electrocatalytic Activity. Chemistry – A European Journal, 29(11): e202202730. doi:10.1002/chem.202202730. [PubMan] : Czysch, C., Dinh, T., Fröder, Y., Bixenmann, L., Komforth, P., Balint, A., Räder, H. J., Naumann, S., & Nuhn, L. (2022). Nontoxic N-Heterocyclic Olefin Catalyst Systems for Well-Defined Polymerization of Biocompatible Aliphatic Polycarbonates. ACS Polymers Au, 2(5), 371-379. doi:10.1021/acspolymersau.2c00017. [PubMan] : Kaps, L., Huppertsberg, A., Choteschovsky, N., Klefenz, A., Durak, F., Schoers, B., Diken, M., Eichler, E., Rosigkeit, S., Schmitt, S., Leps, C., Foerster, F., Bockamp, E., Degeest, B., Marini, F., Koynov, K., Tenzer, S., Schuppan, D., & Nuhn, L. (2022). Bisphosphonate-loaded nanogels attentuate liver fibrosis by repolarization of M2-type macrophages. Journal of Hepatology, 77(Supplement 1): FRI147, S464-S464. [PubMan] : Barz, M., Nuhn, L., Hörpel, G., & Zentel, R. (2022). From Self-Organization to Tumor-Immune Therapy: How Things Started and How They Evolved. Macromolecular Rapid Communications, 43(12): 2100829. doi:10.1002/marc.202100829. [PubMan] : Barz, M., Nuhn, L., & Theato, P. (2022). A Tribute to Rudolf Zentel and His Lifetime Research Achievements. Macromolecular Rapid Communications, 43(12): 2200311. doi:10.1002/marc.202200311. [PubMan] : Huppertsberg, A., Leps, C., Alberg, I., Rosenauer, C., Morsbach, S., Landfester, K., Tenzer, S., Zentel, R., & Nuhn, L. (2022). Squaric Ester‐Based Nanogels Induce No Distinct Protein Corona but Entrap Plasma Proteins into their Porous Hydrogel Network. Macromolecular Rapid Communications, 43(19): 2200318. doi:10.1002/marc.202200318. [PubMan] : Raabe, M., Heck, A., Führer, S., Schauenburg, D., Pieszka, M., Wang, T., Zegota, M. M., Nuhn, L., Ng, D. Y. W., Kuan, S. L., & Weil, T. (2022). Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates. Macromolecular Bioscience, 22(2): 2100299. doi:10.1002/mabi.202100299. [PubMan] : Czysch, C., Medina-Montano, C., Dal, N.-J.-K., Dinh, T. T. D., Fröder, Y., Winterwerber, P., Maxeiner, K., Räder, H. J., Schuppan, D., Schild, H., Bros, M., Biersack, B., Feranoli, F., Grabbe, S., & Nuhn, L. (2022). End Group Dye-labeled Polycarbonate Block Copolymers for Micellar (immuno-)Drug Delivery. Macromolecular Rapid Communications, 2200095. doi:10.1002/marc.202200095. [PubMan] : Kabs, L., Huppertsberg, A., Choteschovsky, N., Klefenz, A., Dural, F., Schrörs, B., Diken, M., Eichler, E., Rosigkeit, S., Schmitt, S., Leps, C., Schulze, A., Foerster, F., Bockamp, E., De Geest, B. G., Koynov, K., Räder, H.-J., Tenzer, S., Marini, F., Schuppan, D., & Nuhn, L. (2022). pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages. Proceedings of the National Academy of Sciences of the United States of America, 119(12): e2122310119. doi:10.1073/pnas.2122310119. [PubMan] : Stickdorn, J., Stein, L., Arnold-Schild, D., Hahlbrock, J., Medina-Montano, C., Bartneck, J., Ziß, T., Montermann, E., Kappel, C., Hobernik, D., Haist, M., Yurugi, H., Raabe, M., Best, A., Rajalingam, K., Radsak, M. P., David, S. A., Koynov, K., Bros, M., Grabbe, S., Schild, H., & Nuhn, L. (2022). Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors. ACS Nano, 16(3), 4426-4443. doi:10.1021/acsnano.1c10709. [PubMan] : Schmitt, S., Huppertsberg, A., Klefenz, A., Kaps, L., Mailänder, V., Schuppan, D., Butt, H.-J., Nuhn, L., & Koynov, K. (2022). Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream. Biomacromolecules, 23(3), 1065-1074. doi:10.1021/acs.biomac.1c01407. [PubMan] : Schmitt, S., Nuhn, L., Barz, M., Butt, H.-J., & Koynov, K. (2022). Shining Light on Polymeric Drug Nanocarriers with Fluorescence Correlation Spectroscopy. Macromolecular Rapid Communications, 43(12): 2100892. doi:10.1002/marc.202100892. [PubMan] : Czysch, C., Medina-Montano, C., Zhong, Z., Fuchs, A., Stickdorn, J., Winterwerber, P., Schmitt, S., Deswarte, K., Raabe, M., Scherger, M., Combes, F., Vrieze, J. D., Kasmi, S., Sandners, N. N., Lienenklaus, S., Koynov, K., Räder, H.-J., Lambrecht, B. N., David, S. A., Bros, M., Schild, H., Grabbe, S., Geest, B. G. D., & Nuhn, L. (2022). Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels. Advanced Functional Materials, 2203490. doi:10.1002/adfm.202203490. [PubMan] : Medina-Montano, C., Stickdorn, J., Haist, M., Nuhn, L., Bros, M., & Grabbe, S. (2022). Biological effects of systemically administered TLR7/8 Agonist and Antigen-conjugated nanogels on immune cell populations. European Journal of Immunology, 52: P246, 366-367. doi:10.1002/eji.202270100. [PubMan]