Researcher Portfolio
Coles, Murray
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, Transmembrane Signal Transduction Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society, Transmembrane Signal Transduction Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society
Researcher Profile
Position: Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society
Position: Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society
Position: Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society
Position: Transmembrane Signal Transduction Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society
Position: Transmembrane Signal Transduction Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society
Additional IDs: MPIB: murray
ORCID: https://orcid.org/0000-0001-6716-6150
ORCID: https://orcid.org/0000-0001-6716-6150
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons271255
Publications
(1 - 25 of 69)
: Boudrioua, A., Joiner, J., Grin, I., Kronenberger, T., Korotkov, V., Steinchen, W., Kohler, A., Schminke, S., Schulte, J.-C., Pietsch, M., Naini, A., Kalverkamp, S., Hotop, S.-K., Coyle, T., Piselli, C., Coles, M., Rox, K., Marschal, M., Bange, G., Flieger, A., Poso, A., Brönstrup, M., Hartmann, M., & Wagner, S. (2025). Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity. Science Advances, 11(15): eadr5235. doi:10.1126/sciadv.adr5235. [PubMan] : Müller, T., Kleusberg, F., Roganowicz, K., Weiss, G., Coles, M., & Selim, K. (submitted). The Ca2+-binding protein CSE links Ca2+-signaling with cell-cell communication in multicellular cyanobacteria. [PubMan] : Klett, T., Stahlecker, J., Jaag, S., Masberg, B., Knappe, C., Lämmerhofer, M., Coles, M., Stehle, T., & Boeckler, F. (2024). Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution. ACS Pharmacology & Translational Science, 7(12), 3984-3999. doi:10.1021/acsptsci.4c00414. [PubMan] : Coles, M. (2024). Toward 4D protein structures: solution ensembles from a NOESY-based R-factor. In 20th European Magnetic Resonance Congress (EUROMAR 2024) (pp. 100). [PubMan] : Boudrioua, A., Joiner, J., Grin, I., Kronenberger, T., Korotkov, V., Steinchen, W., Kohler, A., Schminke, S., Schulte, J.-C., Pietsch, M., Naini, A., Kalverkamp, S., Hotop, S.-K., Coyle, T., Piselli, C., Coles, M., Rox, K., Marscha, M., Bange, G., Flieger, A., Poso, A., Brönstrup, M., Hartmann, M., & Wagner, S. (submitted). Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity. [PubMan] : Garcia, J., Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Topal, B., Millet, O., Orozco, M., Coles, M., Crehuet, R., & Salvatella, X. (2023). Design of a polyglutamine-based helical scaffold to target globular proteins. Poster presented at 19th European Magnetic Resonance Congress (EUROMAR 2023), Glasgow, UK. [PubMan] : Stahlecker, J., Klett, T., Schwer, M., Jaag, S., Dammann, M., Ernst, L., Braun, M., Zimmermann, M., Kramer, M., Lämmerhofer, M., Stehle, T., Coles, M., & Boeckler, F. (2022). Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C. RSC Medicinal Chemistry, 13(12), 1575-1586. doi:10.1039/D2MD00246A. [PubMan] : Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Mateos, B., Garcia-Cabau, C., Sánchez-Navarro, M., Topal, B., Biesaga, M., Staby, L., Kragelund, B., García, J., Millet, O., Orozco, M., Coles, M., Crehuet, R., & Salvatella, X. (2022). A glutamine-based single α-helix scaffold to target globular proteins. Nature Communications, 13(1): 7073. doi:10.1038/s41467-022-34793-6. [PubMan] : Dammann, M., Stahlecker, J., Zimmermann, M., Klett, T., Rotzinger, K., Kramer, M., Coles, M., Stehle, T., & Boeckler, F. (2022). Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes. Journal of Medicinal Chemistry, 65(21), 14539-14552. doi:10.1021/acs.jmedchem.2c00951. [PubMan] : Ptacek, J., Albrecht, R., Dunin-Horkawicz, S., Schultz, J., Coles, M., Hartmann, M., & Lupas, A. (2022). Archaeal receptor Af1503: an ideal model for structural and functional studies of transmembrane signaling. In 8th Alpbach Workshop: Coiled Coil, Fibrous and Repeat Proteins (pp. 54). [PubMan] : Coles, M., Dunin-Horkawicz, S., Hartmann, M., & Lupas, A. (2022). Revisiting HAMP in the AlphaFold age. In 8th Alpbach Workshop: Coiled Coil, Fibrous and Repeat Proteins (pp. 12). [PubMan] : Garcia, J., Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Topal, B., Millet, O., Orozco, M., Coles, M., Crehuet, R., & Salvatella, X. (2022). Design of a glutamine-based single a-helix scaffold to target globular proteins. Poster presented at European Congress on Magnetic Resonance (EUROMAR 2022), Utrecht, The Netherlands. [PubMan] : Skokowa, J., Hernandez Alvarez, B., Coles, M., Ritter, M., Nasri, M., Haaf, J., Aghaallaei, N., Xu, Y., Mir, P., Krahl, A.-C., Rogers, K., Maksymenko, K., Bajoghli, B., Welte, K., Lupas, A., Müller, P., & ElGamacy, M. (2022). A topological refactoring design strategy yields highly stable granulopoietic proteins. Nature Communications, 13(1): 2948. doi:10.1038/s41467-022-30157-2. [PubMan] : Skokowa, J., Hernandez Alvarez, B., Coles, M., Ritter, M., Nasri, M., Haaf, J., Aghaallaei, N., Xu, Y., Mir, P., Krahl, A.-C., Rogers, K., Maksymenko, K., Bajoghli, B., Welte, K., Lupas, A., Müller, P., & ElGamacy, M. (2022). A topological refactoring design strategy yields highly stable granulopoietic proteins. Nature Communications, 13(1): 2948. doi:10.1038/s41467-022-30157-2. [PubMan] : Lupas, A., Pereira, J., Alva, V., Merino, F., Coles, M., & Hartmann, M. (2021). The breakthrough in protein structure prediction. Biochemical Journal, 478(10), 1885-1890. doi:10.1042/BCJ20200963. [PubMan] : Hernandez Alvarez, B., Skokowa, J., Coles, M., Mir, P., Nasri, M., Weidmann, L., Rogers, K., Welte, K., Lupas, A., Müller, P., & ElGamacy, M. (2020). Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biology, 18(12): e3000919. doi:10.1371/journal.pbio.3000919. [PubMan] : Hernandez Alvarez, B., Skokowa, J., Coles, M., Mir, P., Nasri, M., Weidmann, L., Rogers, K., Welte, K., Lupas, A., Müller, P., & ElGamacy, M. (2020). Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biology, 18(12): e3000919. doi:10.1371/journal.pbio.3000919. [PubMan] : Toledo-Patiño, S., Chaubey, M., Coles, M., & Höcker, B. (2019). Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor. Biochemistry, 58(48), 4790-4793. doi:10.1021/acs.biochem.9b00900. [PubMan] : ElGamacy, M., Riss, M., Zhu, H., Truffault, V., & Coles, M. (2019). Mapping Local Conformational Landscapes of Proteins in Solution. Structure, 27(5), 853-865. doi:10.1016/j.str.2019.03.005. [PubMan] : Adlakha, J., Karamichali, I., Sangwallek, J., Deiss, S., Bär, K., Coles, M., Hartmann, M., Lupas, A., & Hernandez Alvarez, B. (2019). Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles. Structure, 27(3), 464-475. doi:10.1016/j.str.2018.11.004. [PubMan] : ElGamacy, M., Coles, M., & Lupas, A. (2018). Asymmetric protein design from conserved supersecondary structures. Journal of Structural Biology, 204(3), 380-387. doi:10.1016/j.jsb.2018.10.010. [PubMan] : Lupas, A., Ferris, H., Bassler, J., Martin, J., Schultz, J., Dunin-Horkawicz, S., Hartmann, M., & Coles, M. (2018). Axial helix rotation in transmembrane signal transduction. Journal of Bioenergetics and Biomembranes, 50(6), 507. [PubMan] : Pereira, J., Rau, A., Coles, M., ElGamacy, M., Fujishima, K., Martin, J., & Lupas, A. (2018). The KH type III domain: From an ancestral peptide to three different protein folds. In Encontro de Jovens Investigadores de Biologia Computacional Estrutural (EJIBCE 2018) (pp. 7-8). [PubMan] : ElGamacy, M., Coles, M., Ernst, P., Zhu, H., Hartmann, M., Plückthun, A., & Lupas, A. (2018). An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synthetic Biology, 7(9), 2226-2235. doi:10.1021/acssynbio.8b00224. [PubMan] : Coles, M. (2018). If I only had an R!. Poster presented at XXVIIIth International Conference on Magnetic Resonance in Biological Systems: Frontier of magnetic resonance in biological systems, Dublin, Ireland. [PubMan]