Researcher Portfolio
Hartmann, Marcus D
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society, Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, X-Ray Crystallography, Max Planck Institute for Biology Tübingen, Max Planck Society, X-Ray Crystallography, Max Planck Institute for Developmental Biology, Max Planck Society
Researcher Profile
Position: Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society
Position: 2022 (Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society)
Position: Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society
Position: Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society
Position: X-Ray Crystallography, Max Planck Institute for Biology Tübingen, Max Planck Society
Position: X-Ray Crystallography, Max Planck Institute for Developmental Biology, Max Planck Society
Additional IDs: MPIB: mhartmann
ORCID: https://orcid.org/0000-0001-6937-5677
ORCID: https://orcid.org/0000-0001-6937-5677
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons271510
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Publications
(1 - 25 of 119)
: Boudrioua, A., Coyle, T., Piselli, C., Pitotti, G., Pietsch, M., Kronenberger, T., Korotkov, V., Maier, L., Flieger, A., Hartmann, M., Brönstrup, M., & Wagner, S. (2025). An anti-virulence strategy to treat Salmonella infections: Development of lead compounds targeting the transcriptional regulator HilD. Poster presented at Gemeinsame DGI/DZIF-Tagung 2025, München, Germany. [PubMan] : Khuzhakhmetova, L., Ananeva, A., Gantin, G., Dar’in, D., Bunev, A., Ebeling, S., Herrmann, A., Hartmann, M., Kalinin, S., & Bakulina, O. (2025). Synthesis of α-(azidomethyl)glutarimide and its applicationin construction of potential Cereblon ligands via the CuAAC reaction. Mendeleev Communications, 35(1), 69-72. doi:10.71267/mencom.7543. [PubMan] : Bell, M., Haag, M., Clasen, S., Boecker, M., Maksymenko, K., Koch, I., Hipp, K., Hartmann, M., Weir, J., Merino, F., & Ley, R. (submitted). Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5. [PubMan] : Bell, M., Haag, M., Clasen, S., Boecker, M., Maksymenko, K., Koch, I., Hipp, K., Hartmann, M., Weir, J., Merino, F., & Ley, R. (submitted). Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5. [PubMan] : Ullrich, T., Klimenkova, O., Pollmann, C., Lasram, A., Hatskovska, V., Maksymenko, K., Milijaš-Jotić, M., Schenk, L., Lengerke, C., Hartmann, M., Piehler, J., Skokowa, J., & ElGamacy, M. (in press). A Strategy to Design Protein-based Antagonists Against Type I Cytokine Receptors. PLOS Biology, 22(11): e3002883. doi:10.1371/journal.pbio.3002883. [PubMan] : Schwab, S., Hu, Y., van Erp, B., Kajili, M., Hartmann, M., Hernandez-Alvarez, B., Alva, V., Boyle, A., & Dame, R. (2024). Novel histones and histone variant families in prokaryotes. Nature Communications, 15(1): 7950. doi:10.1038/s41467-024-52337-y. [PubMan] : Hu, Y., Schwab, S., Deiss, S., Escudeiro, P., van Heesch, T., Joiner, J., Vreede, J., Hartmann, M., Lupas, A., Hernandez Alvarez, B., Alva, V., & Dame, R. (2024). Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending. Nucleic Acids Research, 52(14): gkae485, pp. 8193-8204. doi:10.1093/nar/gkae485. [PubMan] : Hu, Y., Schwab, S., Escudeiro, P., van Heesch, T., Vreede, J., Hartmann, M., Lupas, A., Dame, R., Alva, V., & Hernandez Alvarez, B. (2024). Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending. In Molecular Origins of LIFE (pp. 59). [PubMan] : Pais, S., Schroth, S., Joiner, J., Fauser, P., Hartmann, M., & Wagner, S. (2024). Type III secretion of transmembrane proteins and the case of the Salmonella´s chaperone, SscB. In DGHM & VAAM 2024: 7th Joint Microbiology & Infection Conference (pp. 86-87). [PubMan] : Fuchs, A., Ammelburg, M., & Hartmann, M.(2024). Archaeal peptide recombinase? A novel peptide ligating enzyme. [PubMan] : Shevalev, O., Bischof, L., Sapegin, A., Bunev, A., Grigoreva, O., Kantin, G., Kalinin, S., & Hartmann, M. (2024). Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode. European Journal of Medicinal Chemistry, 270: 116328. doi:10.1016/j.ejmech.2024.116328. [PubMan] : Boudrioua, A., Joiner, J., Grin, I., Kronenberger, T., Korotkov, V., Steinchen, W., Kohler, A., Schminke, S., Schulte, J.-C., Pietsch, M., Naini, A., Kalverkamp, S., Hotop, S.-K., Coyle, T., Piselli, C., Coles, M., Rox, K., Marscha, M., Bange, G., Flieger, A., Poso, A., Brönstrup, M., Hartmann, M., & Wagner, S. (submitted). Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity. [PubMan] : Boudrioua, A., Joiner, J., Grin, I., Kronenberger, T., Korotkov, V., Coyle, T., Steinchen, W., Poso, A., Brönstrup, M., Hartmann, M., & Wagner, S. (2024). An anti-virulence strategy to treat Salmonella infections: Development of lead compounds targeting the transcriptional regulator HilD. Poster presented at 8th AMR Conference: Novel Antimicrobials & AMR Diagnostics, Basel, Switzerland. [PubMan] : Hartmann, M. (2024). From in-solution Structural Dynamics for the Design of CRBN Ligands. Talk presented at 4th Annual Targeted Protein Degradation Europe Summit (TPD 2024). London, UK. 2024-03-19 - 2024-03-21. [PubMan] : Hartmann, M. (2024). TRIM for Tissue Specificity. ACS Medicinal Chemistry Letters, 15(1), 4-5. doi:10.1021/acsmedchemlett.3c00504. [PubMan] : Alexander, L., Durairaj, J., Kryshtafovych, A., Abriata, L., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S., Chen, J., Degroux, S., Ekiert, D., Erlandsen, B., Freddolino, P., Gilzer, D., Greening, C., Grimes, J., Grinter, R., Gurusaran, M., Hartmann, M., Hitchman, C., Keown, J., Kropp, A., Kursula, P., Lovering, A., Lemaitre, B., Lia, A., Liu, S., Logotheti, M., Lu, S., Markússon, S., Miller, M., Minasov, G., Niemann, H., Opazo, F., Phillips jr, G., Davies, O., Rommelaere, S., Rosas-Lemus, M., Roversi, P., Satchell, K., Smith, N., Wilson, M., Wu, K.-L., Xia, X., Xiao, H., Zhang, W., Zhou, Z., Fidelis, K., Topf, M., Moult, J., & Schwede, T. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91(12), 1571-1599. doi:10.1002/prot.26545. [PubMan] : Joiner, J., Steinchen, W., Mozer, N., Kronenberger, T., Bange, G., Poso, A., Wagner, S., & Hartmann, M. (2023). HilE represses the activity of the Salmonella virulence regulator HilD via a mechanism distinct from that of intestinal long-chain fatty acids. The Journal of Biological Chemistry, 299(12): 105387. doi:10.1016/j.jbc.2023.105387. [PubMan] : Fonseca Lopez, F., Miao, J., Damjanovic, J., Bischof, L., Braun, M., Ling, Y., Hartmann, M., Lin, Y.-S., & Kritzer, J. (2023). Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. Journal of Chemical Information and Modeling, 63(21), 6925-6937. doi:10.1021/acs.jcim.3c01337. [PubMan] : Steinebach, C., Bricelj, A., Murgai, A., Sosič, I., Bischof, L., Ng, Y., Heim, C., Maiwald, S., Proj, M., Voget, R., Feller, F., Košmrlj, J., Sapozhnikova, V., Schmidt, A., Zuleeg, M., Lemnitzer, P., Mertins, P., Hansen, F., Gütschow, M., Krönke, J., & Hartmann, M. (2023). Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. Current Medicinal Chemistry, 66(21), 14513-14543. doi:10.1021/acs.jmedchem.3c00851. [PubMan] : Pais, S., Fauser, P., Schroth, S., Joiner, J., Hartmann, M., & Wagner, S. (2023). Type III secretion chaperones and transmembrane proteins: elucidating the mechanisms underlying correct targeting to secretion. Poster presented at 3rd International Conference Controlling Microbes to Fight Infections (CMFI 2023), Tübingen, Germany. [PubMan] : Pais, S., Fauser, A., Joiner, J., Schroth, S., Hartmann, M., Hartmann, M., & Wagner, S. (2023). Development of anti-virulence agents targeting HilD, the central regulator of Salmonella pathogenicity. In 75. DGHM-Jahrestagung (pp. 103). [PubMan] : Boudrioua, A., Joiner, J., Grin, I., Korotkov, V., Kronenberger, T., Kalverkamp, S., Poso, A., Hartmann, M., Brönstrup, M., & Wagner, S. (2023). Development of anti-virulence agents targeting HilD, the central regulator of Salmonella pathogenicity. In 75. DGHM-Jahrestagung (pp. 61). [PubMan] : Kuchta, R., Heim, C., Herrmann, A., Maiwald, S., Ng, Y., Sosič, I., Keuler, T., Krönke, J., Gütschow, M., Hartmann, M., & Steinebach, C. (2023). Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC Chemical Biology, 4(3), 229-234. doi:10.1039/D2CB00223J. [PubMan] : Hu, Y., Deiss, S., Joiner, J., Hartmann, M., Lupas, A., Hernandez Alvarez, B., & Alva, V. (submitted). Atomic resolution structure of a DNA-binding histone protein from the bacterium Bdellovibrio bacteriovorus. [PubMan] : Selim, K., Haffner, M., Mantovani, O., Albrecht, R., Zhu, H., Hagemann, M., Forchhammer, K., & Hartmann, M. (2023). Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA. Proceedings of the National Academy of Sciences of the United States of America, 120(8): e2205882120. doi:10.1073/pnas.2205882120. [PubMan]