Researcher Portfolio

Ph.D. Higuchi, Miyoko

Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society

Researcher Profile

Position: Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society

Researcher ID: https://pure.mpg.de/cone/persons/resource/persons93415

External references

WorldCat Search for Higuchi, Miyoko

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Publications

: Liddicoat, B. J., Piskol, R., Chalk, A. M., Ramaswami, G., Higuchi, M., Hartner, J. C., Li, J. B., Seeburg, P. H., & Walkley, C. R. (2015). RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science, 349(6252), 1115-1120. doi:10.1126/science.aac7049. [PubMan] : Huang, H., Tan, B. Z., Shen, Y., Tao, J., Jiang, F., Sung, Y. Y., Ng, C. K., Raida, M., Köhr, G., Higuchi, M., Fatemi−Shariatpanahi, H., Harden, B., Yue, D. T., & Soong, T. W. (2012). RNA editing of the IQ domain in cav1.3 channels modulates their ca2+-dependent inactivation. Neuron, 73(2), 304-316. doi:10.1016/j.neuron.2011.11.022. [PubMan] : Horsch, M., Seeburg, P. H., Adler, T., Aguilar−Pimentel, J. A., Becker, L., Calzada−Wack, J., Garrett, L., Götz, A., Hans, W., Higuchi, M., Hölter, S. M., Naton, B., Prehn, C., Puk, O., Rácz, I., Rathkolb, B., Rozman, J., Schrewe, A., Adamski, J., Busch, D. H., Esposito, I., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Mempel, M., Ollert, M., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Gailus−Durner, V., Fuchs, H., Hrabe de Angelis, M., & Beckers, J. (2011). Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. The Journal of Biological Chemistry, 286(21), 18614-18622. doi:10.1074/jbc.M110.200881. [PubMan] : Yang, W., Chendrimada, T. P., Wang, Q., Higuchi, M., Seeburg, P. H., Shiekhattar, R., & Nishikura, K. (2006). Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Structural and Molecular Biology, 13(1), 13-21. doi:10.1038/nsmb1041. [PubMan] : Hartner, J. C., Schmittwolf, C., Kispert, A., Müller, A., Higuchi, M., & Seeburg, P. H. (2004). Liver disintegration in the mouse embryo by deficiency in RNA editing enzyme ADAR1. The Journal of Biological Chemistry, 279(6), 4894-4902. doi:10.1074/jbc.M311347200. [PubMan] : Seeburg, P. H., Single, F. N., Kuner, T., Higuchi, M., & Sprengel, R. (2001). Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse. Brain Research, 907(1), 233-243. doi:10.1016/S0006-8993(01)02445-3. [PubMan] : Higuchi, M., Maas, S., Single, F. N., Hartner, J. C., Rozov, A., Burnashev, N., Feldmeyer, D., Sprengel, R., & Seeburg, P. H. (2000). Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature, 406(6791), 78-81. doi:10.1038/35017558. [PubMan] : Sprengel, R., Higuchi, M., Monyer, H., & Seeburg, P. H. (1999). Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy. In A. V. Delgado-Escueta, & H. H. Jasper (Eds.), Jasper's basic mechanisms of the epilepsies: Advances in neurology 3rd. Edition (pp. 525-534). Philadelphia [u.a.]: Lippincott Williams & Wilkins. [PubMan] : Jerecic, J., Single, F. N., Krüth, U., Krestel, H. E., Kolhekar, R., Storck, T., Kask, K., Higuchi, M., Sprengel, R., & Seeburg, P. H. (1999). Studies on conditional gene expression in the brain. Annals of the New York Academy of Sciences, 868, 27-37. doi:10.1111/j.1749-6632.1999.tb11271.x. [PubMan] : Seeburg, P. H., Higuchi, M., & Sprengel, R. (1998). RNA editing of brain glutamate receptor channels: mechanism and physiology. Brain Research Reviews, 26(2-3), 217-229. doi:10.1016/S0165-0173(97)00062-3. [PubMan] : Seeburg, P. H., Brusa, R., Higuchi, M., & Sprengel, R. (1998). Glutamate receptor channels, RNA editing, and epilepsy. Ernst Schering Research Foundation workshop, 23(1), 1-17. [PubMan] : Mittaz, L., Scott, H. S., Rossier, C., Seeburg, P. H., Higuchi, M., & Antonarakis, S. E. (1997). Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. Genomics, 41(2), 210-217. doi:10.1006/geno.1997.4655. [PubMan] : Seeburg, P. H., Brusa, R., Higuchi, M., & Sprengel, R. (1997). Glutamate receptor channels, RNA editing and epilepsy. In Excitatory amino acids: from genes to therapy (Ernst Schering research foundation workshop; 23) (pp. 1-17). Heidelberg: Springer. [PubMan] : Melcher, T., Maas, S., Herb, A., Sprengel, R., Higuchi, M., & Seeburg, P. H. (1996). RED2, a brain specific member of the RNA specific adenosine deaminase family. The Journal of Biological Chemistry, 271(50), 31795-31798. Retrieved from http://www.jbc.org/content/271/50/31795.abstract. [PubMan] : Maas, S., Melcher, T., Herb, A., Seeburg, P. H., Keller, W., Krause, S., Higuchi, M., & O'Connell, M. A. (1996). Structural requirements for RNA editing in glutamate receptor pre-mRNAs by recombinant double-stranded RNA adenosine deaminase. The Journal of Biological Chemistry, 271(21), 12221-12226. doi:10.1074/jbc.271.21.12221. [PubMan] : Herb, A., Higuchi, M., Sprengel, R., & Seeburg, P. H. (1996). Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proceedings of the National Academy of Sciences of the United States of America, 93(5), 1875-1880. Retrieved from http://www.pnas.org/cgi/content/abstract/93/5/1875?maxtoshow%3D%26HITS%3D10%26hits%3D10%26RESULTFORMAT%3D%26searchid%3D1050127900416_1336%26stored_search%3D%26FIRSTINDEX%3D0%26minscore%3D5000%26journalcode%3Dpnas. [PubMan] : Melcher, T., Maas, S., Herb, A., Sprengel, R., Seeburg, P. H., & Higuchi, M. (1996). A mammalian RNA editing enzyme. Nature, 379, 460-464. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8559253. [PubMan] : Sprengel, R., Brusa, R., Melcher, T., Higuchi, M., & Seeburg, P. H. (1996). RNA editing in ionotropic glutamate receptor channels. In S. Nakanishi (Ed.), Taniguchi Symposia on Brain Sciences. − 19: Gene Targeting and New Developments in Neurobiology (pp. 99-113). Basel: Karger. [PubMan] : Melcher, T., Maas, S., Higuchi, M., Keller, W., Seeburg, P. H., Major, G., Larkman, A. U., Jonas, P., Sakmann, B., & Jack, J. J. B. (1995). Editing of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR-B Pre-mRNA in Vitro Reveals Site-selective Adenosine to Inosine Conversion. The Journal of Biological Chemistry, 270(15), 8566-8570. doi:10.1074/jbc.270.15.8566. [PubMan] : Seeburg, P. H., Sprengel, R., Monyer, H., Higuchi, M., Kuner, T., Köhr, G., Herb, A., Mosbacher, J., Jonas, P., & Burnashev, N. (1995). Glutamate Receptor Channels in CNS: Molecular and Functional Aspects. In C.. Bergadà (Ed.), Puberty: basic and clinical aspects. − (Frontiers in endocrinology; 10) (pp. 60-65). Rom: Ares−Serono Symposia Publications. [PubMan] : Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A. W. J., & Seeburg, P. H. (1994). Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science, 266(5191), 1709-1713. doi:10.1126/science.7992055. [PubMan] : Higuchi, M., Single, F. N., Köhler, M., Sommer, B., Sprengel, R., & Seeburg, P. H. (1993). RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency. Cell, 75(7), 1361-1370. doi:10.1016/0092-8674(93)90622-W. [PubMan] : Monyer, H., Sprengel, R., Schöpfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science, 256(5060), 1217-1221. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1350383. [PubMan]