ausblenden:
Schlagwörter:
virus bioinformatics, SARS-CoV-2, sequencing, epidemiology, drug design, tools
Zusammenfassung:
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae.
The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many
years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed
as a rapid reaction to the need for fast detection, understanding, and treatment of COVID-19. To control the
ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of
the virus.
In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection,
the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment
measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic
strategies. For each tool, we briefly describe its use case and how it advances research specifically for
SARS-CoV-2. All tools are freely available online, either through web applications or public code repositories.
