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Language(s):
eng - English
Dates:
2009-03
Publication Status:
Accepted / In Press
Pages:
111
Publishing info:
Berlin : Freien Universität Berlin
Table of Contents:
1 Introduction
1.1 Heart development 1
1.2 Essential factors of transcriptional regulation during cardiogenesis
1.2.1 Signaling molecules and transcription factors 4
1.2.2 Histone modifications and chromatin remodeling 7
1.3 Congenital heart disease 11
2 Aim of the project 16
3 Prediction of cardiac transcription networks based on molecular data and
complex phenotypes
3.1 Synopsis 17
3.2 Experimental contributions 21
Published in Molecular BioSystems; Journal’s page numbering 589-598
DOI:10.1039/b800207j
4 The cardiac transcription network driven by Gata4, Mef2a, Nkx2.5 and Srf
and epigenetic marks
4.1 Synopsis 25
4.2 Experimental contributions 27
4.3 Manuscript 28
In preparation; page numbering 1-20
4.4 Supplemental material 48
5 Characterization of TBX20 in human hearts and its regulation by TFAP2
5.1 Synopsis 73
5.2 Experimental contributions 75
Published in Journal of Cellular Biochemistry; Journal’s page numbering 1022-1033
DOI: 10.1002/jcb.21686
6 Regulation of muscle development by DPF3, a novel histone acetylation and
methylation reader of the BAF chromatin remodeling complex
6.1 Synopsis 79
6.2 Experimental contributions 81
Published in Genes & Development; Journal’s page numbering 2370-2384
DOI: 10.1101/gad.471408
7 Discussion
7.1 Prediction of cardiac transcription networks 83
7.2 Characterization of the transcription factor TBX20 86
7.3 The novel epigenetic regulator DPF3 88
8 References 91
9 Appendix
9.1 Summary 101
9.2 Zusammenfassung 102
9.3 Curriculum Vitae 105
9.4 Acknowledgements 109
9.5 Selbständigkeitserklärung 111
Rev. Type:
-
Identifiers:
eDoc: 444378
Degree:
PhD
