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  Coupling of retrograde flow to force production during malaria parasite migration

Quadt, K., Streichfuss, M., Moreau, C. A., Spatz, J. P., & Frischknecht, F. (2016). Coupling of retrograde flow to force production during malaria parasite migration. ACS Nano, 10(2), 2091-2102. doi:10.1021/acsnano.5b06417.

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http://pubs.acs.org/doi/pdf/10.1021/acsnano.5b06417 (beliebiger Volltext)
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 Urheber:
Quadt, Katherina1, Autor           
Streichfuss, Martin1, 2, Autor           
Moreau, Catherine A., Autor
Spatz, Joachim P.1, 2, Autor           
Frischknecht, Friedrich, Autor
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Schlagwörter: Plasmodium; cell migration; gliding motility; laser traps; malaria; sporozoites
 Zusammenfassung: Migration of malaria parasites is powered by a myosin motor that moves actin filaments, which in turn link to adhesive proteins spanning the plasma membrane. The retrograde flow of these adhesins appears to be coupled to forward locomotion. However, the contact dynamics between the parasite and the substrate as well as the generation of forces are complex and their relation to retrograde flow is unclear. Using optical tweezers we found retrograde flow rates up to 15 μm/s contrasting with parasite average speeds of 1-2 μm/s. We found that a surface protein, TLP, functions in reducing retrograde flow for the buildup of adhesive force and that actin dynamics appear optimized for the generation of force but not for maximizing the speed of retrograde flow. These data uncover that TLP acts by modulating actin dynamics or actin filament organization and couples retrograde flow to force production in malaria parasites.

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Sprache(n): eng - English
 Datum: 2015-10-122016-01-202016-01-272016-02-23
 Publikationsstatus: Erschienen
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
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Titel: ACS Nano
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, DC : American Chemical Society
Seiten: - Band / Heft: 10 (2) Artikelnummer: - Start- / Endseite: 2091 - 2102 Identifikator: Anderer: 1936-0851
CoNE: https://pure.mpg.de/cone/journals/resource/1936-0851