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  Association of estradiol and visceral fat with structural brain networks and memory performance in adults

Zsido, R., Heinrich, M., Slavich, G. M., Beyer, F., Kharabian, S., Kratzsch, J., et al. (2019). Association of estradiol and visceral fat with structural brain networks and memory performance in adults. JAMA Network Open, 2(6): e196126. doi:10.1001/jamanetworkopen.2019.6126.

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Zsido, Rachel1, 2, Autor           
Heinrich, Matthias1, 2, Autor           
Slavich, George M.3, Autor
Beyer, Frauke1, 4, Autor           
Kharabian, Shahrzad1, Autor           
Kratzsch, Jürgen5, Autor
Raschpichler, Matthias6, 7, Autor
Mueller, Karsten8, Autor           
Scharrer, Ulrike1, 2, 9, Autor
Löffler, Markus10, 11, Autor
Schroeter, Matthias L.1, 9, 11, Autor           
Stumvoll, Michael4, 7, Autor
Villringer, Arno1, 9, 11, Autor           
Witte, A. Veronica1, 4, Autor           
Sacher, Julia1, 2, 9, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
3Cousins Center for Psychoneuroimmunology, Department of Psychiatry, University of California, Los Angeles, CA, USA, ou_persistent22              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Heart Center, Helios Hospital, University of Leipzig, Germany, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
11Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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 Zusammenfassung: Importance Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss.

Objectives To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure.

Design, Setting, and Participants Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT as the moderator variable between age and brain network structure and estradiol as the moderator variable between VAT and brain network structure. The study was conducted from August 1, 2011, to November 23, 2014. Analyses were conducted from August 2017 to September 2018

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Sprache(n): eng - English
 Datum: 2019-05-032019-06-21
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1001/jamanetworkopen.2019.6126
PMID: 31225892
PMC: PMC6593958
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : The Branco Weiss Fellowship – Society in Science
Förderorganisation : ETH Zurich
Projektname : -
Grant ID : 25032
Förderprogramm : Young Investigator Grant
Förderorganisation : Brain & Behavior Research Foundation
Projektname : -
Grant ID : 713-241202 ; 14505/2470 ; 14575/2470
Förderprogramm : -
Förderorganisation : LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : European Union (EU)
Projektname : -
Grant ID : -
Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony
Projektname : -
Grant ID : -
Förderprogramm : Minerva Research Group Grant
Förderorganisation : Max Planck Society
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)

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Titel: JAMA Network Open
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Chicago, IL : American Medical Association
Seiten: - Band / Heft: 2 (6) Artikelnummer: e196126 Start- / Endseite: - Identifikator: ISSN: 2574-3805
CoNE: https://pure.mpg.de/cone/journals/resource/2574-3805