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Zusammenfassung:
It has been demonstrated that the hemodynamic signal from individual venules can be detected directly with fMRI. Here, the hemodynamic signal from BOLD and CBV fMRI was measured at high temporal(100ms) and spatial resolution(150x150µm) in layer 4/5 of the rat forepaw S1with fast gradient-echo MRI. Distinctly different voxels were activated in BOLD vs CBV fMRI. In contrast to the BOLD activated voxels primarily located at the penetrating venules, CBV activated voxels were primarily located at penetrating arterioles. This result makes it possible to directly image the CBV and BOLD response at the single-vessel level to understand neurovascular coupling.
