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  Ceramide triggers budding of exosome vesicles into multivesicular endosomes

Trajkovic, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., et al. (2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science, 319(5867), 1244-1247.

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Trajkovic, Katarina, Autor
Hsu, Chieh, Autor
Chiantia, Salvatore, Autor
Rajendran, Lawrence1, Autor           
Wenzel, Dirk, Autor
Wieland, Felix, Autor
Schwille, Petra1, Autor           
Brugger, Britta, Autor
Simons, Mikael, Autor
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of the endosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide. Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation.

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 Datum: 2008
 Publikationsstatus: Erschienen
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 Identifikatoren: eDoc: 414419
Anderer: 1177
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Titel: Science
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 319 (5867) Artikelnummer: - Start- / Endseite: 1244 - 1247 Identifikator: -