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  Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease

Buckle, V. J., Fujita, N., Ryder−Cook, A. S., Derry, J. M. J., Barnard, P. J., Lebo, R. V., et al. (1989). Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron, 3(5), 647-654. doi:10.1016/0896-6273(89)90275-4.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-8505-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-8506-3
Genre: Journal Article

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 Creators:
Buckle, Veronica J., Author
Fujita, Norihisa, Author
Ryder−Cook, Allan S., Author
Derry, Jonathan M. J., Author
Barnard, Pene J., Author
Lebo, Roger V., Author
Schofield, Peter R., Author
Seeburg, Peter H.1, Author           
Bateson, Alan N., Author
Darlison, Mark G., Author
Barnard, Eric A., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Hybridization of GABAA receptor probes to human chromosomes in situ and to DNA from sorted human chromosomes has localized the genes encoding a beta subunit and three isoforms of the alpha subunit. The alpha 2 and beta genes are both located on chromosome 4 in bands p12-p13 and may be adjacent. The alpha 1 gene is on chromosome 5 (bands q34-q35) and the alpha 3 gene is on the X chromosome. The alpha 3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression.

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Language(s): eng - English
 Dates: 1989-02-071989-08-011989-11-01
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0896-6273(89)90275-4
URI: https://www.sciencedirect.com/science/article/pii/0896627389902754
URI: https://www.ncbi.nlm.nih.gov/pubmed/2561974
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 3 (5) Sequence Number: - Start / End Page: 647 - 654 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565