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  Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., et al. (2010). Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging. Cell Stem Cell, 6, 445-456.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8E91-1 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9894-6
Genre: Zeitschriftenartikel

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 Urheber:
Lugert, Sebastian1, Autor           
Basak, Onur2, Autor           
Knuckles, Philip2, Autor           
Haussler, Ute, Autor
Fabel, Klaus, Autor
Götz, Magdalena, Autor
Haas, Carola A., Autor
Kempermann, Gerd, Autor
Taylor, Verdon3, Autor           
Giachino, Claudio2, Autor           
Affiliations:
1Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              
2Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243651              
3Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

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 Zusammenfassung: New neurons are generated in the adult hippocampus throughout life by neural stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external stimuli. We show that canonical Notch signaling through RBP-J is required for hippocampal neurogenesis. Notch signaling distinguishes morphologically distinct Sox2+ NSCs, and within these pools subpopulations can shuttle between mitotically active or quiescent. Radial and horizontal NSCs respond selectively to neurogenic stimuli. Physical exercise activates the quiescent radial population whereas epileptic seizures induce expansion of the horizontal NSC pool. Surprisingly, reduced neurogenesis correlates with a loss of active horizontal NSCs in aged mice rather than a total loss of stem cells, and the transition to a quiescent state is reversible to rejuvenate neurogenesis in the brain. The discovery of multiple NSC populations with Notch dependence but selective responses to stimuli and reversible quiescence has important implications for the mechanisms of adaptive learning and also for regenerative therapy.

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Sprache(n): eng - English
 Datum: 2010-05-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 529887
 Art des Abschluß: -

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Titel: Cell Stem Cell
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 6 Artikelnummer: - Start- / Endseite: 445 - 456 Identifikator: -