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  Rapid feedback processing in human nucleus accumbens and motor thalamus

Schüller, T., Gruendler, T. O., Jocham, G., Klein, T. A., Timmermann, L., Visser-Vandewalle, V., et al. (2015). Rapid feedback processing in human nucleus accumbens and motor thalamus. Neuropsychologia, 70, 246-254. doi:10.1016/j.neuropsychologia.2015.02.032.

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 Urheber:
Schüller, Thomas1, Autor
Gruendler, Theo O.J.1, 2, 3, Autor
Jocham, Gerhard2, 3, Autor
Klein, Tilmann A.4, 5, Autor           
Timmermann, Lars6, Autor
Visser-Vandewalle, Veerle7, Autor
Kuhn, Jens1, Autor
Ullsperger, Markus3, 8, 9, Autor
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Cologne, Germany, ou_persistent22              
2Faculty of Economics and Management, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
3Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, University Hospital Cologne, Germany, ou_persistent22              
7Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Germany, ou_persistent22              
8Institute of Psychology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
9Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Schlagwörter: Nucleus accumbens; Thalamus; Feedback-related negativity; Performance monitoring; Deep brain Stimulation; Time estimation task
 Zusammenfassung: The nucleus accumbens (NAcc) and thalamus are integral parts in models of feedback processing. Deep brain stimulation (DBS) has been successfully employed to alleviate symptoms of psychiatric conditions including obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). Common target structures are the NAcc and the ventral anterior and ventro-lateral nuclei (VA/VL) of the thalamus, for OCD and TS, respectively.

The feedback related negativity (FRN) is an event-related potential associated with feedback processing reflecting posterior medial frontal cortex (pMFC) activity. Here we report on three cases where we recorded scalp EEG and local field potentials (LFP) from externalized electrodes located in the NAcc or thalamus (VA/VL) while patients engaged in a modified time estimation task, known to engage feedback processing and elicit the FRN. Additionally, scalp EEG were recorded from 29 healthy participants (HP) engaged in the same task.

The signal in all structures (pMFC, NAcc, and thalamus) was differently modulated by positive and negative feedback. LFP activity in the NAcc showed a biphasic time course after positive feedback during the FRN time interval. Negative feedback elicited a much weaker and later response. In the thalamus a monophasic modulation was recorded during the FRN time interval. Again, this modulation was more pronounced after positive performance feedback compared to negative feedback. In channels outside the target area no modulation was observed. The surface-FRN was reliably elicited on a group level in HP and showed no significant difference following negative feedback between patients and HP.

German Clinical Trial Register: Neurocognitive specification of dysfunctions within basal ganglia-cortex loops and their therapeutic modulation by deep brain stimulation in patients with obsessive compulsive disorder and Tourette syndrome, http://www.drks.de/DRKS00005316.

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Sprache(n): eng - English
 Datum: 2014-11-052015-02-212015-02-262015-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuropsychologia.2015.02.032
PMID: 25726897
Anderer: Epub 2015
 Art des Abschluß: -

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Titel: Neuropsychologia
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Pergamon
Seiten: - Band / Heft: 70 Artikelnummer: - Start- / Endseite: 246 - 254 Identifikator: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258