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  Biochemical and molecular characterization of the sodium-calcium exchanger from bovine rod photoreceptors

Achilles, A., Friedel, U., Haase, W., Reiländer, H., & Cook, N. J. (1991). Biochemical and molecular characterization of the sodium-calcium exchanger from bovine rod photoreceptors. Annals of the New York Academy of Sciences, 639(1), 234-244. doi:10.1111/j.1749-6632.1991.tb17310.x.

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Genre: Journal Article

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 Creators:
Achilles, Anita1, Author              
Friedel, Ute1, Author              
Haase, Winfried1, Author              
Reiländer, Helmut1, Author              
Cook, Neil J.1, Author              
Affiliations:
1Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068290              

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 Abstract: Vertebrate rod photoreceptors hyperpolarize in response to light by means of the closure of cGMP-gated channels, present in the plasma membrane of the outer segment, which mediate an inwardly directed cation flow referred to as the dark current. Although these channels are most permeable to monovalent cations, they also exhibit an appreciable permeability to the divalent cations Ca2+ and Mg2+. Indeed, calcium ions entering the cell via the cGMP-gated channel constitute 10-15% of the dark current. The sodium-calcium exchanger of rod photoreceptors is responsible for the extrusion of calcium ions entering the outer segment cytosol through the cGMP-gated channel under conditions of darkness. The driving force for this calcium extrusion process is an inwardly directed electrochemical Na+ gradient together with an out wardly directed electrochemical K+ gradient. The stoichiometry of the exchange process under physiological conditions is now accepted to be 4 Nao+: 1 Cai2+ + 1 Ki and is therefore electrogenic.

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Language(s): eng - English
 Dates: 2006-08-171991-12
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Annals of the New York Academy of Sciences
  Other : Ann. N.Y. Acad. Sci.
  Subtitle :
Source Genre: Journal
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Publ. Info: New York : New York Academy of Sciences
Pages: - Volume / Issue: 639 (1) Sequence Number: - Start / End Page: 234 - 244 Identifier: ISSN: 0077-8923
CoNE: https://pure.mpg.de/cone/journals/resource/954926958894_2