hide
Free keywords:
-
Abstract:
The present invention relates to the total chemical synthesis of the monosaccharide 35# (R'-H), the disaccharide 36# (R'<>H; R''-H), the trisaccharide 37# (R'<>H; R''<>H; R'''<>H) and the tetrasaccharide 1# (R'<>H; R''<>H; R'''<>H) of the following general formula wherein R represents -Y-NH2Y represents a linker R' is H or R'' is H or R''' is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or the trisaccharide [alpha]-Hep-(1->3)-[alpha]-Hep-(1->5)-[alpha]-Kdo or [alpha]-GlcNAc-(1->2)-[alpha]-Hep-(1->3)-[alpha]-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.
