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  Towards a comprehensive picture of allo acceptor tRNA remolding in metazoan mitochondrial genomes

Sahyoun, A. H., Hölzer, M., Jühling, F., Höner zu Siederdissen, C., Al-Arab, M., Tout, K., et al. (2015). Towards a comprehensive picture of allo acceptor tRNA remolding in metazoan mitochondrial genomes. Nucleic Acids Research (London), 43, 8044-8056. doi:doi: 10.1093/nar/gkv746.

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Item Permalink: https://hdl.handle.net/someHandle/test/escidoc:902584 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-99A7-3
Genre: Journal Article

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 Creators:
Sahyoun, Abdullah H.1, 2, 3, 4, 5, Author
Hölzer, Martin4, Author
Jühling, Frank1, 2, 6, Author
Höner zu Siederdissen, Christian1, 2, 7, Author
Al-Arab, Marwa1, 2, 3, Author
Tout, Kifah3, Author
Marz, Manja4, 8, 9, Author
Middendorf, Martin10, Author
Stadler, Peter F.1, 2, 6, 7, 11, 12, 13, 14, Author
Bernt, Matthias10, Author
Affiliations:
1Bioinformatics Group, Department of Computer Science, Leipzig University, Leipzig, Germany, ou_persistent22              
2Interdisciplinary Center for Bioinformatics, Leipzig University, Leipzig, Germany, ou_persistent22              
3Doctoral School of Science and Technology, AZM Center for Biotechnology Research, Lebanese University, Tripoli, Lebanon, ou_persistent22              
4RNA Bioinformatics and High Throughput Analysis, Faculty of Mathematics and Computer Sicence, Friedrich Schiller University Jena, Jena, Germany, ou_persistent22              
5Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
6Transcriptome Bioinformatics, LIFE Research Center for Civilzation Diseases, Leipzig University, Leipzig, Germany, ou_persistent22              
7Department of Theoretical Chemisty, University of Vienna, Vienna, Austria, ou_persistent22              
8FLI Leibniz Institute for Age Research, Jena, Germany, ou_persistent22              
9Michael Stifel Center Jena, Jena, Germany, ou_persistent22              
10Parallel Computing and Complex Systems Group, Department of Computer Science, Leipzig University, Leipzig, Germany, ou_persistent22              
11Max-Planck Institute for Mathematics in the Sciences, Leipzig, Germany, ou_persistent22              
12Fraunhofer Institut für Zell Therapie und Immunologie , Leipzig, Germany, ou_persistent22              
13Center for non-coding RNA in Technology and Health, University of Copenhagen, Frederiksberg, Denmark, ou_persistent22              
14Santa Fe Institute , Santa Fe, USA, ou_persistent22              

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 Abstract: Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to tRNAs of a different alloacceptor family than to tRNAs with the same anticodon in related species. Beyond being of interest for understanding mitochondrial tRNA function and evolution, tRNA remolding events can lead to artifacts in the annotation of mitogenomes and thus in studies of mitogenomic evolution. Therefore, it is important to identify and catalog these events. Here we describe novel methods to detect tRNA remolding in large-scale data sets and apply them to survey tRNA remolding throughout animal evolution. We identify several novel remolding events in addition to the ones previously mentioned in the literature. A detailed analysis of these remoldings showed that many of them are derived from ancestral events.

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Language(s): eng - English
 Dates: 2015-09-18
 Publication Status: Issued
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1093/nar/gkv746
 Degree: -

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Title: Nucleic Acids Research (London)
  Other : Nucleic Acids Res
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: 13 Volume / Issue: 43 Sequence Number: - Start / End Page: 8044 - 8056 Identifier: Other: 110992357379342
ISSN: 0305-1048
CoNE: https://pure.mpg.de/cone/journals/resource/110992357379342