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Language(s):
eng - English
Dates:
2007-08
Publication Status:
Accepted / In Press
Pages:
67 p.
Publishing info:
Kiel : Christian-Albrechts-Universität
Table of Contents:
1. Summary 5
2. Deutsche Zusammenfassung 7
3. Introduction 9
3.1 The adaptive immune system 9
3.1.1 An introduction from a theoretical perspective 9
3.1.2 Initiation of a response of the adaptive immune system 10
3.1.3 αß T-cell maturation 10
3.1.4 Types of errors in the detection system of the adaptive immune system 11
3.2 Evolutionary ecology of the MHC 11
4. Parameter estimates and scenario to be modelled 17
4.1 Quantitative estimates of positive selection efficiency 17
4.2 Quantifying negative selection 21
4.3 Estimates for other parameters 26
5. The model 27
5.1 Model development 27
5.2 Evaluation of the model 28
5.3 Comparison with other models 31
5.3.1 Model by Nowak et al. (1992) 31
5.3.2 Model by Borghans et al. (2003) 32
5.3.3 Model by DeBoer and Perelson (1993) 35
6. Other processes influenced by MHC diversity 37
6.1 Risk of autoimmune diseases 37
6.2 Level of antigen presentation 39
7. Outlook: Experimental test of the model predictions 43
7.1 Testable hypotheses and outline of experimental approach 43
7.2 Methods 45
7.2.1 Sectioning 45
7.2.2 Staining 45
7.2.3 Identification of genes of the adaptive immune system in Gasterosteus aculeatus 47
7.3 Results and discussion 47
7.3.1 Histological identification and characterization of the thymus 47
7.3.2 Identification of genes of the adaptive immune system in Gasterosteus aculeatus 52
8. Conclusion 55
9. Literature 57
10. Danksagung 65
11. Stellungnahme 67
Rev. Type:
-
Identifiers:
eDoc: 335022
Other: Dipl/11927
Degree:
Diploma