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Free keywords:
UNFOLDED PROTEIN RESPONSE; PATHWAY
Abstract:
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N-and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.