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  High frequency neural spiking and autitory signaling by ultrafast red-shifted optogenetics

Mager, T., Lopez de la Morena, D., Senn, V., Schlotte, J., D'Errico, A., Feldbauer, K., et al. (2018). High frequency neural spiking and autitory signaling by ultrafast red-shifted optogenetics. Nature Communications, 9: 1750.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0002-7492-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0002-7493-5
Genre: Zeitschriftenartikel

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 Urheber:
Mager, Thomas1, Autor
Lopez de la Morena, David2, Autor
Senn, Verena1, Autor
Schlotte, Johannes1, Autor
D'Errico, Anna1, Autor
Feldbauer, Katrin1, Autor
Wrobel, Christian2, Autor
Jung, Sangyong2, Autor
Bodensiek, Kai2, Autor
Rankovic, Vladan2, Autor
Browne, Lorcan2, Autor
Huet, Antoine2, Autor
Jüttner, Josephine3, Autor
Wood, Philipp G.1, Autor
Letzkus, Johannes J.4, Autor
Moser, Tobias2, Autor
Bamberg, Ernst1, Autor
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, DE, ou_2068289              
2Institute for Auditory Neuroscience and Inner Ear Lab University Medical Center, Göttingen, ou_persistent22              
3Friedrich Miescher Institute for Biomedical Research, Basel, ou_persistent22              
4Max Planck Institute for Brain Research, Max Planck Society, Max-von-Laue-Str. 4, 60438 Frankfurt am Main, DE, ou_2461692              

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 Zusammenfassung: Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applicaitons. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast neural photoactivation over the whole range of the visible spectrum. We focus our functional analysis on the fast-switching, red light-activated Chrimson variants, because red light has lower light scattering and marginal phototoxicity in tissues. We show paradigmatically for neurons of the cerebral cortex and the auditory nerve that the fast Chrimson mutants enable neural stimulation with firing frequencies of serveral hundred Hz. They drive spiking at high rates and temporal fidelity with low thresholds for stimulus intensity and duration. Optical cochlear implants resore auditory nerve activity in deaf mice. This demonstrates that the mutants facilitate neuroscience research and future medical applications such as hearing restoration.

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 Datum: 2018-05-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: PMID: 29717130
PMC: PMC5931537
 Art des Abschluß: -

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Titel: Nature Communications
  Kurztitel : Nat. Commun.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 9 Artikelnummer: 1750 Start- / Endseite: - Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723