The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site 
investigation of the neural mechanisms underlying response to electroconvulsive 
therapy

Oltedal, Leif; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Kessler, Ute; Abbott, Christopher; Dols, Annemieke; Stek, Max L.; Ersland, Lars; Emsell, Louise; van Eijndhoven, Philip; Argyelan, Miklos; Tendolkar, Indira; Nordanskog, Pia; Hamilton, Paul; Jorgensen, Martin Balslev; Sommer, Iris E.; Heringa, Sophie M.; Draganski, Bogdan; Redlich, Ronny; Dannlowski, Udo; Kugel, Harald; Bouckaert, Filip; Sienaert, Pascal; Anand, Amit; Espinoza, Randall; Narr, Katherine L.; Holland, Dominic; Dale, Anders M.; Oedegaard, Ketil J.

doi:10.1016/j.nicl.2017.02.009

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The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Oltedal, L., Bartsch, H., Sørhaug, O. J. E., Kessler, U., Abbott, C., Dols, A., et al. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical, 14, 422-432. doi:10.1016/j.nicl.2017.02.009.

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Oltedal, Leif¹, Autor
Bartsch, Hauke¹, Autor
Sørhaug, Ole Johan Evjenth¹, Autor
Kessler, Ute¹, Autor
Abbott, Christopher¹, Autor
Dols, Annemieke¹, Autor
Stek, Max L.¹, Autor
Ersland, Lars¹, Autor
Emsell, Louise¹, Autor
van Eijndhoven, Philip¹, Autor
Argyelan, Miklos¹, Autor
Tendolkar, Indira¹, Autor
Nordanskog, Pia¹, Autor
Hamilton, Paul¹, Autor
Jorgensen, Martin Balslev¹, Autor
Sommer, Iris E.¹, Autor
Heringa, Sophie M.¹, Autor
Draganski, Bogdan^{1, 2}, Autor
Redlich, Ronny¹, Autor
Dannlowski, Udo¹, Autor
Kugel, Harald¹, AutorBouckaert, Filip¹, AutorSienaert, Pascal¹, AutorAnand, Amit¹, AutorEspinoza, Randall¹, AutorNarr, Katherine L.¹, AutorHolland, Dominic¹, AutorDale, Anders M.¹, AutorOedegaard, Ketil J.¹, Autor mehr..

Affiliations:
1External Organizations, ou_persistent22
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549

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Schlagwörter: Electroconvulsive therapy; MRI; Longitudinal; Mega analysis; Multi-site

Zusammenfassung: Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches.

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Sprache(n): eng - English

Datum: Geändert: 2017-02-09Eingereicht: 2016-12-15Angenommen: 2017-02-10Online veröffentlicht: 2017-02-14

Publikationsstatus: Online veröffentlicht

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Art der Begutachtung: Expertenbegutachtung

Identifikatoren: DOI: 10.1016/j.nicl.2017.02.009
PMC: PMC5328749
PMID: 28275543
Anderer: eCollection 2017

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Förderorganisation : Western Norway Regional Health Authority

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Förderorganisation : Haukeland University Hospital

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Förderorganisation : University of Bergen, Norway

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Förderorganisation : Lundbeck Foundation

Projektname : Neurobiologie affektiver Störungen: Eine translationale Perspektive auf Hirnstruktur und -funktion / FOR 2107

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Förderorganisation : German Research Foundation (DFG)

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Grant ID : RE111604

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Förderorganisation : Innovative Medizinische Forschung

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Grant ID : 2P20GM103472-01

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Förderorganisation : Centers of Biomedical Research Excellence

Projektname : NCCR Synapsy

Grant ID : 32003B_159780

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Förderorganisation : Foundation Synapsis

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Förderorganisation : Roger de Spoelberch and Partridge Foundations

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Grant ID : R01MH092301; K24MH102743

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Förderorganisation : National Institute of Mental Health (NIMH)

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Titel: NeuroImage: Clinical

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: Elsevier

Seiten: - Band / Heft: 14 Artikelnummer: - Start- / Endseite: 422 - 432 Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582

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