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  Oscillatory stimuli differentiate adapting circuit topologies

Rahi, S. J., Larsch, J., Pecani, K., Katsov, A. Y., Mansouri, N., Tsaneva-Atanasova, K., et al. (2017). Oscillatory stimuli differentiate adapting circuit topologies. Nature methods, 14(10), 1010-1016. doi:10.1038/NMETH.4408.

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 Urheber:
Rahi, Sahand Jamal1, Autor
Larsch, Johannes2, Autor           
Pecani, Kresti1, Autor
Katsov, Alexander Y.1, Autor
Mansouri, Nahal1, Autor
Tsaneva-Atanasova, Krasimira1, Autor
Sontag, Eduardo D.1, Autor
Cross, Frederick R.1, Autor
Affiliations:
1external, ou_persistent22              
2Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Schlagwörter: CELL-CYCLE TRANSCRIPTION; FOLD-CHANGE DETECTION; CAENORHABDITIS-ELEGANS; BACTERIAL CHEMOTAXIS; SIGNAL-TRANSDUCTION; PERFECT ADAPTATION; POSITIVE-FEEDBACK; C-ELEGANS; NETWORK; PATHWAYSBiochemistry & Molecular Biology;
 Zusammenfassung: Biology emerges from interactions between molecules, which are challenging to elucidate with current techniques. An orthogonal approach is to probe for 'response signatures' that identify specific circuit motifs. For example, bistability, hysteresis, or irreversibility are used to detect positive feedback loops. For adapting systems, such signatures are not known. Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forward loops (IFFLs). On the basis of computational testing and mathematical proofs, we propose differential signatures: in response to oscillatory stimulation, NFLs but not IFFLs show refractory-period stabilization (robustness to changes in stimulus duration) or period skipping. Applying this approach to yeast, we identified the circuit dominating cell cycle timing. In Caenorhabditis elegans AWA neurons, which are crucial for chemotaxis, we uncovered a Ca2+ NFL leading to adaptation that would be difficult to find by other means. These response signatures allow direct access to the outlines of the wiring diagrams of adapting systems.

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Sprache(n): eng - English
 Datum: 2017-08-282017-10
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000412002700024
DOI: 10.1038/NMETH.4408
 Art des Abschluß: -

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Titel: Nature methods
  Andere : Nature methods
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Nature Pub. Group
Seiten: - Band / Heft: 14 (10) Artikelnummer: - Start- / Endseite: 1010 - 1016 Identifikator: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556