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  Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage

Retailleau, K., Arhatte, M., Demolombe, S., Jodar, M., Baudrie, V., Offermanns, S., et al. (2016). Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468(7), 1151-1160. doi:10.1007/s00424-016-1813-x.

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 Urheber:
Retailleau, Kevin, Autor
Arhatte, Malika, Autor
Demolombe, Sophie, Autor
Jodar, Martine, Autor
Baudrie, Veronique, Autor
Offermanns, Stefan1, Autor           
Feng, Yuanyi, Autor
Patel, Amanda, Autor
Honore, Eric, Autor
Duprat, Fabrice, Autor
Affiliations:
1Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591696              

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Schlagwörter: PERIVENTRICULAR HETEROTOPIA; A MUTATIONS; BINDING; HYPERTENSION; MECHANOPROTECTION; CHANNELS; CELLSPhysiology; Filamin A; Blood pressure; Aorta; Carotid; Contractility; Reactivity; Stiffness; Remodeling;
 Zusammenfassung: Human mutations in the X-linked FLNA gene are associated with a remarkably diverse phenotype, including severe arterial morphological anomalies. However, the role for filamin A (FlnA) in vascular cells remains partially understood. We used a smooth muscle (sm)-specific conditional mouse model to delete FlnA at the adult stage, thus avoiding the developmental effects of the knock-out. Inactivation of smFlnA in adult mice significantly lowered blood pressure, together with a decrease in pulse pressure. However, both the aorta and carotid arteries showed a major outward hypertrophic remodeling, resistant to losartan, and normally occurring in hypertensive conditions. Notably, arterial compliance was significantly enhanced in the absence of smFlnA. Moreover, reactivity of thoracic aorta rings to a variety of vasoconstrictors was elevated, while basal contractility in response to KCl depolarization was reduced. Enhanced reactivity to the thromboxane A2 receptor agonist U46619 was fully reversed by the ROCK inhibitor Y27632. We discuss the possibility that a reduction in arterial stiffness upon smFlnA inactivation might cause a compensatory increase in conduit artery diameter for normalization of parietal tension, independently of the ROCK pathway. In conclusion, deletion of smFlnA in adult mice recapitulates the vascular phenotype of human bilateral periventricular nodular heterotopia, culminating in aortic dilatation.

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Sprache(n): eng - English
 Datum: 2016
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000379849900005
DOI: 10.1007/s00424-016-1813-x
 Art des Abschluß: -

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Titel: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 233 SPRING ST, NEW YORK, NY 10013 USA : SPRINGER
Seiten: - Band / Heft: 468 (7) Artikelnummer: - Start- / Endseite: 1151 - 1160 Identifikator: ISSN: 0031-6768