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  Neuroanatomical correlates of food addiction symptoms and body mass index in the general population

Beyer, F., Garcia-Garcia, I., Heinrich, M., Schroeter, M. L., Sacher, J., Luck, T., Riedel-Heller, S. G., Stumvoll, M., Villringer, A., & Witte, A. V. (2019). Neuroanatomical correlates of food addiction symptoms and body mass index in the general population. Human Brain Mapping. doi:10.1002/hbm.24557.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-2C85-6 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-AB78-6
資料種別: 学術論文

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作成者

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 作成者:
Beyer, Frauke1, 2, 著者           
Garcia-Garcia, Isabel1, 3, 著者           
Heinrich, Matthias1, 著者
Schroeter, Matthias L.1, 4, 著者           
Sacher, Julia1, 著者           
Luck, Tobias5, 著者
Riedel-Heller, Steffi G.5, 著者
Stumvoll, Michael6, 著者
Villringer, Arno1, 4, 著者           
Witte, A. Veronica1, 2, 著者           
所属:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              

内容説明

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キーワード: Body mass index; Cohort studies; Eating; Food addiction; Gray matter; Neuroimaging; Obesity
 要旨: The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Participants of the LIFE-Adult study (n = 625; 20–59 years old, 45% women) answered the Yale Food Addiction Scale (YFAS) and further personality measures, underwent anthropometric assessments and high-resolution 3T-neuroimaging. A higher YFAS symptom score correlated with higher BMI, eating behavior traits, neuroticism, and stress. Higher BMI predicted significantly lower thickness of (pre)frontal, temporal and occipital cortex and increased volume of left nucleus accumbens. In a whole-brain analysis, YFAS symptom score was not associated with significant differences in cortical thickness or subcortical gray matter volumes. A hypothesis-driven Bayes factor analysis suggested a small, additional contribution of YFAS symptom score to lower right lateral orbitofrontal cortex thickness over the effect of BMI. Our study indicates that symptoms of food addiction do not account for the major part of the structural brain differences associated with BMI in the general population. Yet, symptoms of food addiction might explain additional variance in orbitofrontal cortex, a hub area of the reward network. Longitudinal studies implementing both anatomical and functional MRI could further disentangle the neural mechanisms of addictive eating behaviors.

資料詳細

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言語: eng - English
 日付: 2019-01-152018-10-152019-02-142019-02-28
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1002/hbm.24557
PMID: 30816616
その他: Epub ahead of print
 学位: -

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Project information

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Project name : -
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Funding program : European Social Fund
Funding organization : European Commission (EC)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Grant ID : 713‐241202
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Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
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Grant ID : 14505/2470
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Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : Obesity mechanisms / SFb 1052
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Funding organization : German Research Foundation (DFG)
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Funding program : Branco Weiss Fellowship - Society in Science
Funding organization : ETH Zurich
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Grant ID : 25034
Funding program : NARSAD Young Investigator Award
Funding organization : Brain and Behavior Research Foundation
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Funding program : -
Funding organization : Max Planck Society

出版物 1

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出版物名: Human Brain Mapping
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: New York : Wiley-Liss
ページ: - 巻号: - 通巻号: - 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686