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  Imaging in vivo: watching the brain in action

Kerr, J. N., & Denk, W. (2008). Imaging in vivo: watching the brain in action. Nature Reviews. Neuroscience, 9(3), 195-205. doi:10.1038/nrn2338.

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Kerr, J. N.1, Author
Denk, W., Author
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Free keywords: Animals Brain/cytology/*physiology *Brain Mapping Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging/*methods *Models, Neurological Neurons/*physiology/ultrastructure
 Abstract: The appeal of in vivo cellular imaging to any neuroscientist is not hard to understand: it is almost impossible to isolate individual neurons while keeping them and their complex interactions with surrounding tissue intact. These interactions lead to the complex network dynamics that underlie neural computation which, in turn, forms the basis of cognition, perception and consciousness. In vivo imaging allows the study of both form and function in reasonably intact preparations, often with subcellular spatial resolution, a time resolution of milliseconds and a purview of months. Recently, the limits of what can be achieved in vivo have been pushed into terrain that was previously only accessible in vitro, due to advances in both physical-imaging technology and the design of molecular contrast agents.

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 Dates: 2008
 Publication Status: Issued
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 Identifiers: Other: 18270513
DOI: 10.1038/nrn2338
ISSN: 1471-0048 (Electronic)
ISSN: 1471-003X (Linking)
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Title: Nature Reviews. Neuroscience
  Alternative Title : Nat. Rev. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 195 - 205 Identifier: -