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Schlagwörter:
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Zusammenfassung:
We established a multi-modal fMRI platform with two-channel fiber optic recording based on a genetically encoded fluorescent reporter, iGluSnFR, for extracellular glutamate (Glu) sensing and intracellular calcium indicator, GCaMP6f. Different from the intracellular neuronal and astrocytic calcium transients, the Glu signal, peak responses of spikes and baseline drift, show unique correlation features to the BOLD fMRI signal. Here, we applied the multi-modal fMRI platform to decipher the cellular and molecular interaction underlying the BOLD fMRI signal through the neuro-glio-vascular network in animal brains.
