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  Identification of a Wnt/DVI/β-catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development

Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., et al. (2002). Identification of a Wnt/DVI/β-catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell, 111(5), 673-685.

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 Creators:
Kioussi, Chrissa, Author
Briata, Paola, Author
Baek, Sung H., Author
Rose, David W., Author
Hamblet, Natasha S., Author
Herman, Thomas, Author
Ohgi, Kenneth A., Author
Lin, Chijen J., Author
Gleiberman, Anatoli, Author
Wang, Jianbo, Author
Brault, Veronique1, Author              
Ruiz-Lozano, Pilar, Author
Nguyen, H. D., Author
Kemler, Rolf2, Author              
Glass, Christopher K., Author
Wynshaw-Boris, Anthony, Author
Rosenfeld, Michael G., Author
Affiliations:
1Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243651              
2Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

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 Abstract: Understanding the cell type-specific molecular mechanisms by which distinct signaling pathways combinatorially control proliferation during organogenesis is a central issue in development and disease. Here, we report that the bicoid- related transcription factor Pitx2 is rapidly induced by the Wnt/Dvl/β-catenin pathway and is required for effective cell-type-specific proliferation by directly activating specific growth-regulating genes. Regulated exchange of HDACi/β-catenin converts Pitx2 from repressor to activator, analogous to control of TCF/LEFT. Pitx2 then serves as a competence factor required for the temporally ordered and growth factor-dependent recruitment of a series of specific coactivator complexes that prove necessary for Cyclin D2 gene induction. The molecular strategy underlying interactions between the Wnt and growth factor-dependent signaling pathways in cardiac outflow tract and pituitary proliferation is likely to be prototypic of cell-specific proliferation strategies in other tissues.

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Language(s): eng - English
 Dates: 2002-11-27
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 20931
ISI: 000179594500009
 Degree: -

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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 111 (5) Sequence Number: - Start / End Page: 673 - 685 Identifier: ISSN: 0092-8674