非表示:
キーワード:
PROTECTING GROUPS; CHEMISTRYACETYLESTERASE FROM ORANGE PEEL; PENICILLIN G ACYLASE; ENZYMATIC DEPROTECTION; CARBOHYDRATES; NUCLEOSIDES;
要旨:
The enzyme acetyl esterase from the flavedo of oranges (EC 3.1.1.6) chemo- and regioselectively removes acetyl groups from carbohydrates and nucleosides. The chemoselective enzymatic liberation of the amino functions present in the nucleobases of O-acetylated nucleosides is achieved by penicillin G acylase (EC 3.5.1.11) mediated hydrolysis of the corresponding phenylacetamides.