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  Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

Rombold, F., Lauterbach, E., Felber, W., Mueller-Oerlinghausen, B., Ahrens, B., Bronisch, T., et al. (2014). Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 18(4), 300-303. doi:10.3109/13651501.2014.940052.

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 Urheber:
Rombold, Felicitas1, Autor
Lauterbach, Eric1, Autor
Felber, Werner1, Autor
Mueller-Oerlinghausen, Bruno1, Autor
Ahrens, Bernd1, Autor
Bronisch, Thomas2, Autor           
Kilb, Birgit1, Autor
Lewitzka, Ute1, Autor
Richter, Kneginja1, Autor
Broocks, Andreas1, Autor
Heuser, Isabella1, Autor
Hohagen, Fritz1, Autor
Quante, Arnim1, Autor
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Zusammenfassung: Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet. Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted. Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention. Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.

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Sprache(n): eng - English
 Datum: 2014-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000344473900013
DOI: 10.3109/13651501.2014.940052
 Art des Abschluß: -

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Titel: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Informa plc
Seiten: - Band / Heft: 18 (4) Artikelnummer: - Start- / Endseite: 300 - 303 Identifikator: ISSN: 1365-1501