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  Effect of acyl chain composition on salt-induced lamellar to inverted hexagonal phase transitions in cardiolipin.

Sankaram, M. B., Powell, G. L., & Marsh, D. (1989). Effect of acyl chain composition on salt-induced lamellar to inverted hexagonal phase transitions in cardiolipin. Biochimica et Biophysica Acta (BBA) - Biomembranes, 980(3), 389-392. doi:10.1016/0005-2736(89)90331-3.

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Sankaram, M. B.1, Author              
Powell, G. L., Author
Marsh, D.1, Author              
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1Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society, ou_578624              

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 Abstract: Salt-induced fluid lamellar (Lα) to inverted hexagonal (HII) phase transitions have been studied in diphosphatidyl-glycerols (cardiolipins) with different acyl chain compositions, using 31P nuclear magnetic resonance (NMR) spectroscopy. Cardiolipins with four myristoyl chains, tetramyristoyl cardiolipin (TMCL), and with four oleoyl chains, tetraoleoyl cardiolipin (TOCL), were synthesized chemically. TMCL was found to undergo a thermotropic lamellar gel to lamellar liquid-crystalline phase transition at 33–35°C. This lipid exhibited an axially symmetric 31P-NMR spectrum corresponding to a lamellar phase at all NaCl concentrations between 0 and 6 M. In the case of TOCL, formation of an HII phase was induced by salt concentrations of 3.5 M NaCl or greater. These observations, taken together with earlier findings that bovine heart cardiolipin aqueous dispersions adopt an HII phase at salt concentrations of 1.5 M NaCl or greater, indicate that increasing unsaturation and length of the acyl chains favour formation of the HII phase in diphosphatidylglycerols.

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Language(s): eng - English
 Dates: 1989-04-28
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0005-2736(89)90331-3
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Title: Biochimica et Biophysica Acta (BBA) - Biomembranes
Source Genre: Journal
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Pages: - Volume / Issue: 980 (3) Sequence Number: - Start / End Page: 389 - 392 Identifier: -