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  A forceful connection: mechanoregulation of oncogenic YAP

Böttcher, R. T., Sun, Z., & Fässler, R. (2017). A forceful connection: mechanoregulation of oncogenic YAP. The EMBO Journal, 36(17), 2467-2469. doi:10.15252/embj.201797527.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-0001-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-0002-0
Genre: Journal Article

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2467.full.pdf (Publisher version), 571KB
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 Creators:
Böttcher, Ralph Thomas1, Author           
Sun, Zhiqi2, Author
Fässler, Reinhard1, Author           
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2external, ou_persistent22              

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Free keywords: TRANSCRIPTIONAL REGULATION; CELL-PROLIFERATION; GENE-TRANSCRIPTION; BREAST-CANCER; MECHANOTRANSDUCTION; RECEPTOR; AIB1Biochemistry & Molecular Biology; Cell Biology;
 Abstract: The Yes-associated protein (YAP) is an important transcriptional co-activator that mediates the cellular response to mechanical and cytoskeletal cues. In two recent papers published in The EMBO Journal, Dae-Sik Lim and colleagues show how YAP activity affects cancer formation and metastasis via a crosstalk with myocardin-related transcription factors (MRTFs; Kim et al, 2017) and SKP2-dependent cell cycle progression

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Language(s): eng - English
 Dates: 2017
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000408828500001
DOI: 10.15252/embj.201797527
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Title: The EMBO Journal
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 36 (17) Sequence Number: - Start / End Page: 2467 - 2469 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1