Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells

Buffa, L., Fuchs, E., Pietropaolo, M., Barr, F., & Solimena, M. (2008). ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. European Journal of Cell Biology, 87(4), 197-209.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Buffa, Laura1, Autor           
Fuchs, Evelyn, Autor
Pietropaolo, Massimo, Autor
Barr, Francis, Autor
Solimena, Michele1, Autor           
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Islet cell autoantigen of 69kDa (ICA69) is a small GTPase-binding protein of unknown function. ICA69 is enriched in the Golgi complex and its N-terminal half contains a BAR domain, a module that can bind/bend membranes and interacts with phospholipids. Here we show that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex. Rab2 binds to ICA69 in a GTP-dependent fashion and recruits it to membranes. Over-expression of either Rab2 or ICA69 in INS-1 cells results in a phenotype characterized by: (i) impaired anterograde transport of the secretory granule protein precursors pro-ICA512 and chromogranin A; (ii) reduction of stimulated insulin secretion. Taken together, these data identify ICA69 as a novel Rab2 effector and point to its role in regulating the early transport of insulin secretory granule proteins.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2008
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 414348
Anderer: 1051
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: European Journal of Cell Biology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 87 (4) Artikelnummer: - Start- / Endseite: 197 - 209 Identifikator: -