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  Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution

Armache, J. P., Jarasch, A., Anger, A. M., Villa, E., Becker, T., Bhushan, S., et al. (2010). Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Preceedings of the National Academy of Sciences USA, 107(46), 19748-19753. doi:10.1073/pnas.1009999107.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-79EC-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-79ED-3
Genre: Journal Article
Alternative Title : Proc Natl Acad Sci USA

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 Creators:
Armache, J. P., Author
Jarasch, A., Author
Anger, A. M., Author
Villa, E., Author
Becker, T., Author
Bhushan, S., Author
Jossinet, F., Author
Habeck, M., Author
Dindar, G., Author
Franckenberg, S., Author
Marquez, V., Author
Mielke, T.1, Author           
Thomm, M., Author
Berninghausen, O., Author
Beatrix, B., Author
Soding, J., Author
Westhof, E., Author
Wilson, D. N.2, Author           
Beckmann, R., Author
Affiliations:
1Imaging/Electron Microscopy (Head: Rudi Lurz/Thorsten Mielke), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479668              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: Cryoelectron Microscopy; Crystallography, X-Ray; Escherichia coli/metabolism/ultrastructure; Eukaryotic Cells/metabolism/ultrastructure; Humans; Models, Molecular; Protein Biosynthesis; RNA, Ribosomal/ultrastructure; Ribosomes/chemistry/metabolism/ultrastructure; Saccharomyces cerevisiae/metabolism/ultrastructure; Triticum/metabolism/ultrastructure
 Abstract: Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-A resolution. This map, together with a 6.1-A map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model approximately 98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

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Language(s): eng - English
 Dates: 2010-11-16
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 541905
DOI: 10.1073/pnas.1009999107
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Title: Preceedings of the National Academy of Sciences USA
  Alternative Title : Proc Natl Acad Sci USA
Source Genre: Journal
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Pages: - Volume / Issue: 107 (46) Sequence Number: - Start / End Page: 19748 - 19753 Identifier: ISSN: 1091-6490 (Electronic)