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  Inhibition of the mitochondrial tricarboxylate carrier by arginine-specific reagents

Stipani, I., Zara, V., Zaki, L., Prezioso, G., & Palmieri, F. (1986). Inhibition of the mitochondrial tricarboxylate carrier by arginine-specific reagents. FEBS Letters, 205(2), 282-286. doi:10.1016/0014-5793(86)80913-9.

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 Creators:
Stipani, I.1, Author
Zara, V.1, Author
Zaki, Laila2, Author              
Prezioso, G.1, Author
Palmieri, F.1, Author
Affiliations:
1Department of Pharmaco-Biology, Laboratory of Biochemistry, University of Bari, CNR Unit for the Study of Mitochondria and Bioenergetics, 70126 Bari, Italy, ou_persistent22              
2Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_3264817              

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Free keywords: Tricarboxylate carrier; Arginine-specific reagent; Mitochondria; Membrane transport; (Rat liver)
 Abstract: The effect of arginine-specific reagents on the activity of the partially purified and reconstituted tricarboxylate carrier of the inner mitochondrial membrane has been studied. It has been found that 1,2-cyclohexanedione, 2,3-butanedione, phenylglyoxal and phenylglyoxal derivatives inhibit the reconstituted citrate/citrate exchange activity. The inhibitory potency of the phenylglyoxal derivatives increases with increasing hydrophilic character of the molecule. Citrate protects the tricarboxylate carrier against inactivation caused by the arginine-specific reagents. Other tricarboxylates, which are not substrates of the carrier, have no protective effect. The results indicate that at least one essential arginine residue is located at the substrate-binding site of the tricarboxylate carrier and that the vicinity of the essential arginine(s) has a hydrophilic character.

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Language(s): eng - English
 Dates: 1986-06-302001-11-121986-09-15
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0014-5793(86)80913-9
PMID: 3743778
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
 Creator(s):
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 205 (2) Sequence Number: - Start / End Page: 282 - 286 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501