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  The immunopeptidomic landscape of ovarian carcinomas

Schuster, H., Peper, J. K., Boesmueller, H.-C., Roehle, K., Backert, L., Bilich, T., et al. (2017). The immunopeptidomic landscape of ovarian carcinomas. Proceedings of the National Academy of Sciences of the United States of America, 114(46), E9942-E9951. doi:10.1073/pnas.1707658114.

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http://www.pnas.org/content/114/46/E9942 (Verlagsversion)
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 Urheber:
Schuster, Heiko1, Autor
Peper, Janet K.1, Autor
Boesmueller, Hans-Christian1, Autor
Roehle, Kevin1, Autor
Backert, Linus1, Autor
Bilich, Tatjana1, Autor
Ney, Britta1, Autor
Loeffler, Markus W.1, Autor
Kowalewski, Daniel J.1, Autor
Trautwein, Nico1, Autor
Rabsteyn, Armin1, Autor
Engler, Tobias1, Autor
Braun, Sabine1, Autor
Haen, Sebastian P.1, Autor
Walz, Juliane S.1, Autor
Schmid-Horch, Barbara1, Autor
Brucker, Sara Y.1, Autor
Wallwiener, Diethelm1, Autor
Kohlbacher, Oliver1, 2, Autor
Fend, Falko1, Autor
Rammensee, Hans-Georg1, AutorStevanovic, Stefan1, AutorStaebler, Annette1, AutorWagner, Philipp1, Autor mehr..
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute for Developmental Biology, Max Planck Society, Max-Planck-Ring 5, 72076 Tübingen, DE, ou_2421691              

Inhalt

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Schlagwörter: T-CELLS; CANCER-IMMUNOTHERAPY; ADVANCED MELANOMA; IMMUNE PRIVILEGE; TUMOR; ANTIGENS; MESOTHELIN; SURVIVAL; IDENTIFICATION; EXPRESSION; immunopeptidome; ovarian cancer; immunotherapy; mucin 16; mesothelin;
 Zusammenfassung: Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer therapy by releasing the power of the immune system. However, only little is known about the antigens that are essentially presented on cancer cells, capable of exposing them to immune cells. Large-scale HLA ligandome analysis has enabled us to exhaustively characterize the immunopeptidomic landscape of epithelial ovarian cancers (EOCs). Additional comparative profiling with the immunopeptidome of a variety of benign sources has unveiled a multitude of ovarian cancer antigens (MUC16, MSLN, LGALS1, IDO1, KLK10) to be presented by HLA class I and class II molecules exclusively on ovarian cancer cells. Most strikingly, ligands derived from mucin 16 and mesothelin, a molecular axis of prognostic importance in EOC, are prominent in a majority of patients. Differential gene-expression analysis has allowed us to confirm the relevance of these targets for EOC and further provided important insights into the relationship between gene transcript levels and HLA ligand presentation.

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Sprache(n): eng - English
 Datum: 2017-05-082017-10-102017-11-012017-11-14
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000415173300028
DOI: 10.1073/pnas.1707658114
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proceedings of the National Academy of Sciences of the USA
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 114 (46) Artikelnummer: - Start- / Endseite: E9942 - E9951 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230