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  Automated synthesis of chondroitin sulfate oligosaccharides

Liang, C.-F., Hahm, H. S., & Seeberger, P. H. (2015). Automated synthesis of chondroitin sulfate oligosaccharides. Methods in Molecular Biology, 1229, 3-10. doi:10.1007/978-1-4939-1714-3_1.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0006-DCCE-B Version Permalink: https://hdl.handle.net/21.11116/0000-0006-DCCF-A
Genre: Journal Article

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Chapter.pdf (Publisher version), 468KB
 
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 Creators:
Liang, Chien-Fu1, Author           
Hahm, Heung Sik2, Author           
Seeberger, Peter H.3, Author           
Affiliations:
1Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
3Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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 Abstract: Glycosaminoglycans (GAGs) are important sulfated carbohydrates prevalently found in the extracellular matrix that serve many biological functions. The synthesis of structurally diverse but defined GAGs is extremely challenging as one has to account for the various sulfation patterns. Described is the automated synthesis of two chondroitin sulfate hexasaccharides. The oligosaccharides are prepared on a solid support that is equipped with a photolabile linker. The linker cleavage from the resin is performed in a continuous-flow photoreactor under chemically mild conditions. The described approach will serve as a general scheme to systematically access oligosaccharides of all GAG families.

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 Dates: 2015
 Publication Status: Issued
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 Identifiers: DOI: 10.1007/978-1-4939-1714-3_1
Other: Liang2015
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Title: Methods in Molecular Biology
  Other : Methods Mol. Biol.
Source Genre: Journal
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Publ. Info: New York : Springer
Pages: - Volume / Issue: 1229 Sequence Number: - Start / End Page: 3 - 10 Identifier: ISSN: 1064-3745

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Title: Glycosaminoglycans
Source Genre: Book
 Creator(s):
Balagurunathan, Kuberan, Editor
Nakato, Hiroshi, Editor
Desai, Umesh R, Editor
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Publ. Info: New York : Humana Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 978-1-4939-1713-6