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  Expanding the toolbox of photoswitches for DNA nanotechnology using Arylazopyrazoles

Adam, V., Prusty, D. K., Centola, M., Skugor, M., Hannam, J. S., Valero, J., et al. (2018). Expanding the toolbox of photoswitches for DNA nanotechnology using Arylazopyrazoles. Chemistry – A European Journal, 24(5), 1062-1066. doi:10.1002/chem.201705500.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-52F3-E Version Permalink: https://hdl.handle.net/21.11116/0000-0008-8620-C
Genre: Journal Article

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Adam_et_al-2018-Chemistry_-_A_European_Journal.pdf (Publisher version), 920KB
 
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https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201705500 (Abstract)
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 Creators:
Adam, Volker1, Author
Prusty, Deepak K.2, Author
Centola, Mathias1, Author
Skugor, Marko1, Author
Hannam, Jeffrey S.1, Author
Valero, Julian2, Author
Kloeckner, Bernhard1, Author
Famulok, Michael2, Author
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1External Organizations, ou_persistent22              
2Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173681              

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 Abstract: Photoregulation is among the most promising tools for development of dynamic DNA nanosystems, due to its high spatiotemporal precision, biocompatibility, and ease of use. So far, azobenzene and its derivatives have shown high potential in photocontrolling DNA duplex hybridization by light-dependent photoisomerization. Despite many recent advances, obtaining sufficiently high photoswitching efficiency under conditions more suitable for work with DNA nanostructures are challenging. Here we introduce a pair of arylazopyrazoles as new photoswitches for efficient and reversible control of DNA hybridization achieved even at room temperature with a low number of required modifications. Their photophysical properties in the native state and in DNA strands result in near-quantitative isomerization rates by irradiation with UV and orange light. To demonstrate the applicability of these photoswitches, we have successfully applied one of them to open and close a DNA hairpin by light at room temperature.

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Language(s): eng - English
 Dates: 2018-01-24
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: ISI: 000427316700011
DOI: 10.1002/chem.201705500
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Title: Chemistry – A European Journal
  Abbreviation : Chem Eur J
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 24 (5) Sequence Number: - Start / End Page: 1062 - 1066 Identifier: ISSN: 0947-6539
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058