English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., et al. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 9: 2098. doi:10.1038/s41467-018-04362-x.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0001-780D-B Version Permalink: https://hdl.handle.net/21.11116/0000-0005-0F32-3
Genre: Journal Article

Files

show Files
hide Files
:
Davies_Lam_2017.pdf (Publisher version), 4MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0001-FE3D-E
Name:
Davies_Lam_2017.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Davies, Gail1, Author
Lam, Max1, Author
Harris, Sarah E.1, Author
Trampush, Joey W.1, Author
Luciano, Michelle1, Author
Hill, W. David1, Author
Hagenaars, Saskia P.1, Author
Ritchie, Stuart J.1, Author
Marioni, Riccardo E.1, Author
Fawns-Ritchie, Chloe1, Author
Liewald, David C. M.1, Author
Okely, Judith A.1, Author
Ahola-Olli, Ari V.1, Author
Barnes, Catriona L. K.1, Author
Bertram, Lars1, Author
Bis, Joshua C.1, Author
Burdick, Katherine E.1, Author
Christoforou, Andrea1, Author
DeRosse, Pamela1, Author
Djurovic, Srdjan1, Author
Espeseth, Thomas1, AuthorGiakoumaki, Stella1, AuthorGiddaluru, Sudheer1, AuthorGustavson, Daniel E.1, AuthorHayward, Caroline1, AuthorHofer, Edith1, AuthorIkram, M. Arfan1, AuthorKarlsson, Robert1, AuthorKnowles, Emma1, AuthorLahti, Jari1, AuthorLeber, Markus1, AuthorLi, Shuo1, AuthorMather, Karen A.1, AuthorMelle, Ingrid1, AuthorMorris, Derek1, AuthorOldmeadow, Christopher1, AuthorPalviainen, Teemu1, AuthorPayton, Antony1, AuthorPazoki, Raha1, AuthorPetrovic, Katja1, AuthorReynolds, Chandra A.1, AuthorSargurupremraj, Muralidharan1, AuthorScholz, Markus1, AuthorSmith, Jennifer A.1, AuthorSmith, Albert V.1, AuthorTerzikhan, Natalie1, AuthorThalamuthu, Anbupalam1, AuthorTrompet, Stella1, Authorvan der Lee, Sven J.1, AuthorWare, Erin B.1, AuthorWindham, B. Gwen1, AuthorWright, Margaret J.1, AuthorYang, Jingyun1, AuthorYu, Jin1, AuthorAmes, David1, AuthorAmin, Najaf1, AuthorAmouyel , Philippe1, AuthorAndreassen, Ole A.1, AuthorArmstrong, Nicola J.1, AuthorAssareh, Amelia A.1, AuthorAttia, John R.1, AuthorAttix, Deborah1, AuthorAvramopoulos, Dimitrios1, AuthorBennett, David A.1, AuthorBöhmer, Anne C.1, AuthorBoyle, Patricia A.1, AuthorBrodaty, Henry1, AuthorCampbell, Harry1, AuthorCannon, Tyrone D.1, AuthorCirulli, Elizabeth T.1, AuthorCongdon, Eliza1, AuthorConley, Emily Drabant1, AuthorCorley, Janie1, AuthorCox, Simon R.1, AuthorDale, Anders M.1, AuthorDehghan, Abbas1, AuthorDick, Danielle1, AuthorDickinson, Dwight1, AuthorEriksson, Johan G.1, AuthorEvangelou, Evangelos1, AuthorFaul, Jessica D.1, AuthorFord, Ian1, AuthorFreimer, Nelson A.1, AuthorGao, He1, AuthorGiegling, Ina1, AuthorGillespie, Nathan A.1, AuthorGordon, Scott D.1, AuthorGottesman, Rebecca F.1, AuthorGriswold, Michael E.1, AuthorGudnason, Vilmundur1, AuthorHarris, Tamara B.1, AuthorHartmann, Annette M.1, AuthorHatzimanolis, Alex1, AuthorHeiss, Gerardo1, AuthorHolliday, Elizabeth G.1, AuthorJoshi, Peter K.1, AuthorKähönen, Mika1, AuthorKardia, Sharon L. R.1, AuthorKarlsson, Ida1, AuthorKleineidam, Luca1, AuthorKnopman, David S.1, AuthorKochan, Nicole A.1, AuthorKonte, Bettina1, AuthorKwok, John B.1, AuthorLe Hellard, Stephanie1, AuthorLee, Teresa1, AuthorLehtimäki, Terho1, AuthorLiu, Tian1, AuthorLi, Shu-Chen1, AuthorKoini, Marisa1, AuthorLondon, Edythe1, AuthorLongstreth Jr, Will T.1, AuthorLopez, Oscar L.1, AuthorLoukola, Anu1, AuthorLuck, Tobias1, AuthorLundervold, Astri J.1, AuthorLundquist, Anders 1, AuthorLyytikäinen, Leo-Pekka1, AuthorMartin, Nicholas G.1, AuthorMontgomery, Grant W.1, AuthorMurray, Alison D.1, AuthorNeed, Anna C.1, AuthorNoordam, Raymond1, AuthorNyberg, Lars1, AuthorOllier, William1, AuthorPapenberg, Goran1, AuthorPattie, Alison1, AuthorPolasek, Ozren1, AuthorPoldrack, Russell A.1, AuthorPsaty, Bruce M.1, AuthorReppermund, Simone1, AuthorRiedel-Heller, Steffi G.1, AuthorRose, Richard J.1, AuthorRotter, Jerome I.1, AuthorRoussos, Panos1, AuthorRovio, Suvi P.1, AuthorSaba, Yasaman1, AuthorSabb, Fred W.1, AuthorSachdev, Perminder S.1, AuthorSatizabal, Claudia L.1, AuthorSchmid, Matthias1, AuthorScott, Rodney J.1, AuthorScult, Matthew A.1, AuthorSimino, Jeannette1, AuthorSlagboom, P. Eline1, AuthorSmyrnis, Nikolaos1, AuthorSoumaré, Aïcha1, AuthorStefanis, Nikos C.1, AuthorStott, David J.1, AuthorStraub, Richard E.1, AuthorSundet, Kjetil1, AuthorTaylor, Adele M.1, AuthorTaylor , Kent D. 1, AuthorTzoulaki, Ioanna1, AuthorTzourio, Christophe1, AuthorUitterlinden, André1, AuthorVitart, Veronique1, AuthorVoineskos, Aristotle N.1, AuthorKaprio, Jaakko1, AuthorWagner, Michael1, AuthorWagner, Holger1, AuthorWeinhold, Leonie1, AuthorWen, K. Hoyan1, AuthorWiden, Elisabeth1, AuthorYang, Qiong1, AuthorZhao, Wei1, AuthorAdams, Hieab H. H.1, AuthorArking, Dan E.1, AuthorBilder, Robert M.1, AuthorBitsios, Panos1, AuthorBoerwinkle, Eric1, AuthorChiba-Falek, Ornit1, AuthorCorvin, Aiden1, AuthorDe Jager, Philip L.1, AuthorDebette, Stéphanie1, AuthorDonohoe, Gary1, AuthorElliott, Paul1, AuthorFitzpatrick, Annette L.1, AuthorGill, Michael1, AuthorGlahn, David C.1, AuthorHägg, Sara1, AuthorHansell , Narelle K.1, AuthorHariri, Ahmad R.1, AuthorIkram, M. Kamran 1, AuthorJukema, J. Wouter1, AuthorVuoksimaa, Eero1, AuthorKeller, Matthew C.1, AuthorKremen, William S.1, AuthorLauner, Lenore1, AuthorLindenberger, Ulman1, AuthorPalotie, Aarno1, AuthorPedersen, Nancy L.1, AuthorPendleton, Neil1, AuthorPorteous, David J.1, AuthorRäikkönen, Katri1, AuthorRaitakari, Olli T.1, AuthorRamirez, Alfredo1, AuthorReinvang, Ivar1, AuthorRudan, Igor1, AuthorRujescu, Dan1, AuthorSchmidt, Reinhold1, AuthorSchmidt, Helena1, AuthorSchofield, Peter W.1, AuthorSchofield, Peter R.1, AuthorStarr, John M.1, AuthorSteen, Vidar M.1, AuthorTrollor, Julian N.1, AuthorTurner, Steven T.1, AuthorVan Duijn, Cornelia M.1, AuthorVillringer, Arno1, 2, Author           Weinberger, Daniel R.1, AuthorWeir, David R.1, AuthorWilson, James F.1, AuthorMalhotra, Anil1, AuthorMcIntosh, Andrew M.1, AuthorGale, Catharine R.1, AuthorSeshadri, Sudha1, AuthorMosley Jr, Thomas H.1, AuthorBressler, Jan1, AuthorLencz, Todd1, AuthorDeary, Ian J.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: -
 Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

Details

show
hide
Language(s): eng - English
 Dates: 2017-08-312018-04-232018-05-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-018-04362-x
PMID: 29844566
PMC: PMC5974083
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : MR/K026992/1
Funding program : -
Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : R01 AG033193 ; U01 AG049505 ; U01 AG052409
Funding program : -
Funding organization : National Institute on Aging
Project name : -
Grant ID : -
Funding program : -
Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)

Source 1

show
hide
Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 2098 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723