Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 DetailsÜbersicht
  Testosterone imbalance may link depression and increased body weight in premenopausal women

Stanikova, D., Zsido, R., Luck, T., Pabst, A., Enzenbach, C., Bae, Y. J., et al. (2019). Testosterone imbalance may link depression and increased body weight in premenopausal women. Translational Psychiatry, 9: 160. doi:10.1038/s41398-019-0487-5.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-CA6D-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-ECC3-7
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Stanikova_2019.pdf (Verlagsversion), 781KB
Öffnen   Speichern
Datei-Permalink:
https://hdl.handle.net/21.11116/0000-0003-CA6F-E
Name:
Stanikova_2019.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Öffnen
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Stanikova, Daniela 1, 2, 3, Autor
Zsido, Rachel4, Autor           
Luck, Tobias 5, 6, Autor
Pabst, Alexander 1, Autor
Enzenbach, Cornelia 5, 7, Autor
Bae, Yoon Ju 8, Autor
Thiery, Joachim 5, 8, Autor
Ceglarek, Uta 5, 8, Autor
Engel, Christoph 5, 7, Autor
Wirkner, Kerstin 5, Autor
Stanik, Juraj 1, 2, 9, Autor
Kratzsch, Juergen 8, Autor
Villringer, Arno3, 10, Autor           
Riedel-Heller, Steffi G. 6, Autor
Sacher, Julia3, 10, Autor           
Affiliations:
1Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, ou_persistent22              
2Department of Pediatrics, Medical Faculty, Comenius University, Bratislava, Slovakia, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Economic & Social Sciences, University of Applied Sciences Nordhausen, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
7Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
8Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
9Center for Pediatric Research Leipzig (CPL), University Hospital Leipzig, Germany, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences in fat accumulation and depression prevalence, as well as the likely role of sex hormones in both overweight and mood disorders, we hypothesised that the depression-overweight association may be mediated by sex hormones. To this end, we investigated the association of being overweight with depression, and then considered the role of sex hormones in relation to being overweight and depression in a large population-based cohort. We included a total of 3124 women, 970 premenopausal and 2154 postmenopausal from the LIFE-Adult cohort study in our analyses. We evaluated associations between being overweight (BMI >25 kg/m2), sex hormone levels, and depressive symptomatology according to Centre for Epidemiologic Studies Depression (CES-D) scores, and explored mediation of depression in a mediation model. Being overweight was significantly associated with depressive symptoms in premenopausal but not postmenopausal women. Both premenopausal and postmenopausal overweight women had higher free testosterone levels compared with normal weight women. Premenopausal women with depressive symptomatology had higher free testosterone levels compared to women without. We found a significant mediation effect of depressive symptomatology in overweight premenopausal women through free testosterone level. These findings highlight the association between being overweight and depressed, and suggest that high free testosterone levels may play a significant role in depression of overweight premenopausal women. Based on this, pharmacological approaches targeting androgen levels in overweight depressed females, in particular when standard anti-depressive treatments fail, could be of specific clinical relevance.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019-03-232018-09-262019-04-022019-06-07
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41398-019-0487-5
PMID: 31175272
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : European Union (EU)
Projektname : -
Grant ID : -
Förderprogramm : European Social Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony
Projektname : -
Grant ID : 01EO1501
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : -
Förderprogramm : Branco Weiss Fellowship - Society in Science
Förderorganisation : ETH Zurich
Projektname : -
Grant ID : -
Förderprogramm : NARSAD Young Investigator Award
Förderorganisation : Brain and Behavior Research Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : European Society for Paediatric Endocrinology (ESPE)

Quelle 1

einblenden:
ausblenden:
Titel: Translational Psychiatry
  Kurztitel : Transl Psychiatry
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Nature Pub. Group
Seiten: - Band / Heft: 9 Artikelnummer: 160 Start- / Endseite: - Identifikator: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188