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  The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b

Brettschneider, J., Ecker, D., Bitsch, A., Bahner, D., Bogumil, T., Dressel, A., et al. (2002). The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. Journal of Neuroimmunology, 133(1-2), 193-197.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A003-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A004-D
Genre: Journal Article
Alternative Title : J. Neuroimmunol.

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 Creators:
Brettschneider, J.1, Author
Ecker, D1, Author
Bitsch, A1, Author
Bahner, D1, Author
Bogumil, T1, Author
Dressel, A1, Author
Elitok, E1, Author
Kitze, B1, Author
Poser, S1, Author
Weber, F1, Author
Tumani, H.1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: multiple sclerosis; primary progressive; relapsing remitting; macrophage activity; sCD14; interferon beta
 Abstract: The soluble form of the CD14 molecule (sCD14), a macrophage activity marker, was measured in the plasma of 17 patients with primary progressive multiple sclerosis (PPMS) and 20 patients with relapsing remitting MS (RRMS). In patients with PPMS, sCD14 levels were determined before and after treatment with interferon beta (IFNB). In both PPMS and in RRMS, sCD14 levels were significantly elevated compared to healthy controls. In patients with PPMS, sCD14 levels increased significantly during the first 3 months of IFNB therapy, then slightly decreased, but still remained elevated compared with levels before therapy. Therefore, the elevated sCD14 levels may be a marker in evaluating biological response to IFNB therapy. (C) 2002 Elsevier Science B.V. All rights reserved

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Language(s): eng - English
 Dates: 2002-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4025
ISI: 000179874700020
 Degree: -

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Title: Journal of Neuroimmunology
  Alternative Title : J. Neuroimmunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 133 (1-2) Sequence Number: - Start / End Page: 193 - 197 Identifier: ISSN: 0165-5728