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Abstract:
A large body of published work shows that proton (hydrogen
1 [1H]) magnetic resonance (MR) spectroscopy has
evolved from a research tool into a clinical neuroimaging
modality. Herein, the authors present a summary of brain
disorders in which MR spectroscopy has an impact on patient
management, together with a critical consideration
of common data acquisition and processing procedures.
The article documents the impact of 1H MR spectroscopy
in the clinical evaluation of disorders of the central nervous
system. The clinical usefulness of 1H MR spectroscopy has
been established for brain neoplasms, neonatal and pediatric
disorders (hypoxia-ischemia, inherited metabolic
diseases, and traumatic brain injury), demyelinating disorders,
and infectious brain lesions. The growing list of
disorders for which 1H MR spectroscopy may contribute
to patient management extends to neurodegenerative diseases,
epilepsy, and stroke. To facilitate expanded clinical
acceptance and standardization of MR spectroscopy
methodology, guidelines are provided for data acquisition
and analysis, quality assessment, and interpretation. Finally,
the authors offer recommendations to expedite the
use of robust MR spectroscopy methodology in the clinical
setting, including incorporation of technical advances on
clinical units.
