Arginase I is constitutively expressed in human granulocytes and participates 
in fungicidal activity

Munder, Markus; Mollinedo, Faustino; Calafat, Jero; Canchado, Javier; Gil-Lamaignere, Cristina; Fuentes, José M.; Luckner, Claudia; Doschko, Gwendolyn; Soler, Germán; Eichamnn, Klaus; Müller, Frank-Michael; Ho, Anthony D.; Goerner, Martin; Modolell, Manuel

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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

Munder, M., Mollinedo, F., Calafat, J., Canchado, J., Gil-Lamaignere, C., Fuentes, J. M., et al. (2005). Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood, 105, 2549-2556.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-932F-3 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9330-E

Genre: Journal Article

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Creators:
Munder, Markus, Author
Mollinedo, Faustino, Author
Calafat, Jero, Author
Canchado, Javier, Author
Gil-Lamaignere, Cristina, Author
Fuentes, José M., Author
Luckner, Claudia, Author
Doschko, Gwendolyn, Author
Soler, Germán, Author
Eichamnn, Klaus¹, Author
Müller, Frank-Michael, Author
Ho, Anthony D., Author
Goerner, Martin, Author
Modolell, Manuel², Author

Affiliations:
1Max Planck Society, ou_persistent13
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649

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Abstract: The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important determinant of the inflammatory response of murine macrophages and dendritic cells. Here we analyzed the expression of the isoform arginase I in human myeloid cells. Using healthy donors and patients with arginase I deficiency, we found that in human leukocytes arginase I is constitutively expressed only in granulocytes and is not modulated by a variety of proinflammatory and anti-inflammatory stimuli in vitro. We demonstrate that arginase I is localized in azurophil granules of neutrophils and constitutes a novel antimicrobial effector pathway, likely through arginine depletion in the phagolysosome. Our findings demonstrate important differences between murine and human leukocytes with respect to regulation and function of arginine metabolism via arginase.

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Language(s): eng - English

Dates: Date issued: 2005-03-15

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 264730

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Title: Blood

Source Genre: Journal

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Pages: - Volume / Issue: 105 Sequence Number: - Start / End Page: 2549 - 2556 Identifier: -