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Free keywords:
Alkylidyne complexes; Alkynes; Macrocycles; Metathesis; Tungsten
Abstract:
A tungsten alkylidyne catalyst is the key to achieving ring-closing metatheses of diynes to form functionalized macrocycles [Eq. (a)]. Partial reduction of the cycloalkynes provides stereoselective Z-configured cycloalkenes, which are currently inaccessible by conventional alkene metathesis.