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  IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

Stanczak, M. A., Sanin, P. D. E., Apostolova, P., Nerz, G., Lampaki, D., Hofmann, M., et al. (2021). IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications, 12, 2133. doi:10.1038/s41467-021-22449-w.

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 Creators:
Stanczak, Michal A1, Author
Sanin, Pena David Estaban1, Author              
Apostolova, Petya1, Author
Nerz, Gabi2, Author              
Lampaki, Dimitrios2, Author
Hofmann, Maike3, Author
Steinmann, Daniel3, Author
Krohn-Grimberghe, Marvin3, Author
Thimme, Robert3, Author
Mittler, Gerhard2, Author              
Waller, Cornelius F3, Author
Pearce, Edward Jonathen1, Author              
Pearce, Erika Laine1, Author              
Affiliations:
1Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243648              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              
3External Organizations, ou_persistent22              

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 Abstract: Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still developing. We perform an observational study to investigate seroprevalence and immune responses in subjects professionally exposed to SARS-CoV-2 and their family members (155 individuals; ages 5-79 years). Seropositivity for SARS-CoV-2 Spike glycoprotein aligns with PCR results that confirm the previous infection. Anti-Spike IgG/IgM titers remain high 60 days post-infection and do not strongly associate with symptoms, except for fever. We analyze PBMCs from a subset of seropositive and seronegative adults. TLR7 agonist-activation reveals an increased population of IL-6+TNF-IL-1β+ monocytes, while SARS-CoV-2 peptide stimulation elicits IL-33, IL-6, IFNa2, and IL-23 expression in seropositive individuals. IL-33 correlates with CD4+ T cell activation in PBMCs from convalescent subjects and is likely due to T cell-mediated effects on IL-33-producing cells. IL-33 is associated with pulmonary infection and chronic diseases like asthma and COPD, but its role in COVID-19 is unknown. Analysis of published scRNAseq data of bronchoalveolar lavage fluid (BALF) from patients with mild to severe COVID-19 reveals a population of IL-33-producing cells that increases with the disease. Together these findings show that IL-33 production is linked to SARS-CoV-2 infection and warrant further investigation of IL-33 in COVID-19 pathogenesis and immunity.

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Language(s): eng - English
 Dates: 2021-04-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-22449-w
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: 2133 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723