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  Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

Wang, J., Thingholm, L. B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J. R., et al. (2016). Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48, 1396-1406. doi:10.1038/ng.3695.

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 Urheber:
Wang, Jun1, Autor           
Thingholm, Louise B, Autor
Skiecevičienė, Jurgita, Autor
Rausch, Philipp1, Autor           
Kummen, Martin, Autor
Hov, Johannes R, Autor
Degenhardt, Frauke, Autor
Heinsen, Femke-Anouska, Autor
Rühlemann, Malte C, Autor
Szymczak, Silke, Autor
Holm, Kristian, Autor
Esko, Tönu, Autor
Sun, Jun, Autor
Pricop-Jeckstadt, Mihaela, Autor
Al-Dury, Samer, Autor
Bohov, Pavol, Autor
Bethune, Jörn, Autor
Sommer, Felix, Autor
Ellinghaus, David, Autor
Berge, Rolf K, Autor
Hübenthal, Matthias, AutorKoch, Manja, AutorSchwarz, Karin, AutorRimbach, Gerald, AutorHübbe, Patricia, AutorPan, Wei-Hung, AutorSheibani-Tezerji, Raheleh, AutorHäsler, Robert, AutorRosenstiel, Philipp, AutorD'Amato, Mauro, AutorCloppenborg-Schmidt, Katja, AutorKünzel, Sven2, Autor           Laudes, Matthias, AutorMarschall, Hanns-Ulrich, AutorLieb, Wolfgang, AutorNöthlings, Ute, AutorKarlsen, Tom H, AutorBaines, John F.1, Autor           Franke, Andre, Autor mehr..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Schlagwörter: Genome-wide association studies; Microbial genetics
 Zusammenfassung: Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr−/− mice relative to control mice and correlations between the microbiota and serum measurements of selected bile and fatty acids in humans, including known ligands and downstream metabolites of VDR. Genome-wide significant (P < 5 × 10−8) associations at multiple additional loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components. Non-genetic and genetic factors each account for approximately 10% of the variation in gut microbiota, whereby individual effects are relatively small.

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Sprache(n): eng - English
 Datum: 2016-04-292016-09-152016-10-10
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/ng.3695
PMID: 27723756
 Art des Abschluß: -

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Titel: Nature Genetics
  Andere : Nature Genet.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Nature America, Inc.
Seiten: - Band / Heft: 48 Artikelnummer: - Start- / Endseite: 1396 - 1406 Identifikator: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609